The prognosis* for Pseudomyxoma Peritonei, Mucinous Adenocarcinoma, Peritoneal Carcinomatosis , Mucinous Cystadenoma******Disseminated Peritoneal Adenomucinosis aka DPAM, Signet Ring Cell and Appendix Cancer has improved during the past decade, with earlier detection, enhanced education of healthcare providers, including radiologists and pathologists, followed by referrals to specialists, and improved methods of treatment.
Treatment** for the Pseudomyxoma Peritonei syndrome, and related diseases, generally includes surgery, with or without systemic or intraperitoneal heated chemotherapy (HIPEC).
During cytoreductive surgery for the treatment of Pseudomyxoma Peritonei syndrome, mucinous tumors are removed. The removal of these tumors may possibly involve the resection or removal of other organs or tissues to which the tumors have become attached.
HIPEC or Hyperthermic Intraperitoneal Chemotherapy, for the treatment of Pseudomyxoma Peritonei syndrome, may be administered if complete tumor debulking is accomplished through cytoreductive surgery. The HIPEC treatment includes the infusion of the abdominal cavity with a specific chemotherapy, heated to approximately 40 degrees Celsius for a period of approximately 90 minutes. The purpose of the HIPEC treatment is to attempt to kill any tumor cells which were not removed during the actual surgery process.
Due to several factors, radiation has not been an effective form of treatment for Pseudomyxoma Peritonei syndrome.
Clinics and hospitals specializing in the treatment of Pseudomyxoma Peritonei are listed on our
Surgeons & Specialists link.
The average age of diagnosis for the Pseudomyxoma Peritonei syndrome is approximately 44 years of age. As few as several hundred cases are diagnosed in the United States annually, with hundreds more in Europe, Asia, Australia,and Canada. It appears that, most likely due to a lack of appropriate diagnostics and medical care, fewer cases are diagnosed in South America, Africa and Mexico. Due to the rarity of diagnosis, Pseudomyxoma Peritonei has been designated as an "orphan disease."
View "Pal Profiles" and photos of patients living successfully following the diagnosis of Pseudomyxoma Peritonei.
Pseudomyxoma Peritonei syndrome symptoms ***may include pain in the lower right quadrant, a feeling of "bloating", abdominal distension, digestive disturbances, loss of appetite, inability to eat a complete meal, constipation and/or diarrhea, shortness of breath, the "appearance" of a "hernia" or other vague symptoms. Pseudomyxoma Peritonei symptoms may appear to be vague, and therefore, may initially be overlooked or misdiagnosed.
What is Pseudomyxoma Peritonei?
What is "PMP?"
The designation of the Pseudomyxoma Peritonei syndrome is divided into four categories that may be designated as follows:
(1) Mucinous Ascites: acellular mucin is present in the peritoneum;
(2) Organized mucinous fluid: mucin has excited a peritoneal response of granulation tissue and inflammatory cells;
(3) Disseminated Peritoneal Adenomucinosis aka DPAM: intraperitoneal mucin with epithelium showing low-grade atypia; the presence of mucin outside the right lower quadrant of the abdomen may indicate a more challenging prognosis.
(4) Peritoneal Mucinous Carcinomatosis: mucin accompanied by abundant malignant epithelium, high-grade atypia (Ronnett et al, 1995). Mucinous Carcinomatosis indicates a more challenging prognosis relative to the more common pattern of Disseminated Peritoneal Adenomucinosis aka DPAM.
Accurate diagnosis of Pseudomyxoma Peritonei requires thorough sampling and investigation by both experienced surgeon(s) and pathologist(s.)
Pseudomyxoma Peritonei Treatment Resources
How can I learn more about PMP?
Can I talk directly with other patients and their families?
To begin seeking resources for the treatment of Pseudomyxoma Peritonei, Peritoneal Carcinomatosis and Appendix Cancer and related diseases, patients should obtain a copy of one's own pathology report**** to read how your particular case has been identified.
To obtain more detailed resources for treatment of Pseudomyxoma Peritonei syndrome, to receive our printed newsletters, monthly email bulletins, publications, and to communicate directly via telephone, email, personal visits or SKYPE, with other patients and family caregivers affected by this disease, you are invited to subscribe to and join the PMP Pals' Network.
Let us know if you would like to speak directly with other patients or family caregivers, diagnosed with, or affected by Pseudomyxoma Peritonei!
Here are additional online resources describing the diagnosis and treatment of the Pseudomyxoma Peritonei syndrome and Appendix Cancer, in general:
Pseudomyxoma Peritonei Prognosis*
What is the prognosis for "PMP?"
The prognosis* for Pseudomyxoma Peritonei, has improved during the past decade, with earlier detection, enhanced education of healthcare providers, including radiologists and pathologists, followed by referrals to specialists, and improved methods of treatment.
Pseudomyxoma Peritonei Prognosis following serial debulking (long term study)
Source: Helskinki Univ Central Hospital, Finland, June 2009
Pseudomyxoma Peritonei Prognosis Long Term Survival (Ten Year Study)
Source: Annals of Surgical Oncology 2009, Prof David L Morris, St George Hospital
Pseudomyxoma Peritonei Prognosis for VEGH expression patients with Mucinous Adenocarcinoma of the Appendix
Source: Annals of Surgical Oncology 2008
Pseudomyxoma Peritonei Prognosis following Chemo Hyperthermic Profusion
Source: Fukai School of Medicine, Japan, April 2009
Pseudomyxoma Peritonei prognosis: biologic features affecting prognosis
Source: Annals of Surgical Oncology 2009
Pseudomyxoma Peritonei prognosis following surgery and HIPEC
Source: Pub Med, Feb 2009
Pseudomyxoma Peritonei prognosis evaluating tumor markers following surgery and HIPEC
Source: Annals of Surgical Oncology, 2008
Pseudomyxoma Peritonei prognosis following HIPEC treatment
Source: ASCO 2007
Pseudomyxoma Peritonei and Peritonei Carcinomatosis Prognosis Indicators
Source: Pub Med 2005
Pseudomyxoma Peritonei Treatment: Library of Medical Publications
Source: Pub Med 2009
Appendix Cancer Library including Pseudomyxoma Peritonei Treatment and Prognosis: Multiple Medical Publications
Source: Pub Med 2009
Analysis of 46 Pseudomyxoma Peritonei patients' prognosis following "second look" surgery
Source: Dr Paul Sugarbaker 2000
Are cases of Appendix Cancer and Pseudomyxoma Peritonei syndrome increasing?
Source: PMP Pals' Network
Pseudomyxoma Peritonei Treatment**
What is the treatment for PMP?
Treatment for Pseudomyxoma Peritonei, and related diseases, generally includes surgery, with or without systemic or intraperitoneal heated chemotherapy (HIPEC).
During cytoreductive surgery for Pseudomyxoma Peritonei, mucinous tumors are removed. The removal of these tumors may possibly involve the resection or removal of other organs or tissues to which the tumors have become attached.
Due to several factors, radiation has not been an effective form of treatment for Pseudomyxoma Peritonei.
Additional resources for the treatment of Pseudomyxoma Peritonei and Appendix Cancer are listed on our Treatments, Chemotherapy, HIPEC, Surgery and Surgeons & Specialists links.
Read the "Pal Profiles" of Pseudomyxoma Peritonei patients who are living active lives following treatment!
Here are a selection of articles related to Pseudomyxoma Peritonei treatment:
Aetna Insurance Approves Payment for CRS with HIPEC for Pseudomyxoma Peritonei
Source: Aetna, 2009
Pleural Pseudomyxoma Peritonei Treatment with Thoracic CRS and HIPEC
Source: University of New South Wales, Austrailia, 2009
Pseudomyxoma Peritonei Treatment with CRS and HIPEC
Source: Universite de Montreal, Canada, 2009
Pseudomyxoma Peritonei Treatment with Chemo Hyperthermic Perfusion(CHPP)
Source: Pub Med 2009
Pseudomyxoma Peritonei Treatment: Safety of Gastric Resection with Cytoreductive Surgery and HIPEC
Source: Annals of Surgical Oncology 2009, Prof P Piso
Pseudomyxoma Peritonei Treatment of Malignant Peritoneal Tumors
Source: Presse Med 2009, Prof FN Gilly, Prof O Glehen
Pseudomyxoma Peritonei Treatment with Cytoreductive Surgery and HIPEC
Source: British Journal of Surgery, Aug 2008
Pseudomyxoma Peritonei Treatment with Avastin and Xeloda
Source: Cancer Bio Ther (Austria and China) Aug 2009
Pseudomyxoma Peritonei Treatment Advances in Peritoneal Surface Oncology by S. González-Moreno
Source: Dr S Gonzalez-Moreno
Pseudomyxoma Peritonei Treatment:
“Appendiceal Carcinoma with Peritoneal Dissemination"by Dr Edward Levine, Wake Forest University
Source: Annals of Surgical Oncology, 2007
Pseudomyxoma Peritonei Treatment at Leopold Park Clinic, Brussels, Belgium (includes graphic illustrations)
Source: Dr. Stefaan Mulier 2009
Pseudomyxoma Peritonei Treatment at Koch Cancer Center
Source: UPMC
Pseudomyxoma Peritonei Treatment and Appendix Cancer Treatment at Moores Cancer Center, UCSD
Source: UCSD
Pseudomyxoma Peritonei Treatment at St Agnes Hospital
Source: St Agnes Hospital, Dr Jesus Esquivel
Pseudomyxoma Peritonei Treatment with Adjuvant Chemotherapy
Source: World Journal of Surgical Oncology 2008
Peritonectomy, Surgical Treatment for Pseudomyxoma Peritonei
Source: Dr H Muller
Pseudomyxoma Peritonei Treatment: Peritoneal Mucinous Carcinomatosis Marker
Source: BioMedical Central 2007
Pseudomyxoma Peritonei Treatment Evaluation of Perioperative Chemotherapy Agents
Source: The Oncologist, Dr Paul Sugarbaker, Feb 2005
Cox II expression in patients with Pseudomyxoma Peritonei and Disseminated Peritoneal Adenomucinosis
Source: Dr Brian Loggie
Pseudomyxoma Peritonei Treatment:
Pseudomyxoma Peritonei: Research Focuses on Possible Link Between Pseudomyxoma Peritonei and Enteric Bacteria (pdf)
Pseudomyxoma Peritonei Treatment:“Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy
Source: Dr Paul F Mansfield,Annals of Surgical Oncology 2007
Pseudomyxoma Peritonei Treatment "Second Look Surgery" Study of 312 Patients
Source: Dr Paul Sugarbaker, Washington Hospital Center, 2000
Pseudomyxoma Peritonei Treatment with Adjuvant Chemotherapy
Source: World Journal of Surgical Oncology, China, 2008
Are you seeking additional resources for the treatment of Pseudomyxoma Peritonei or Appendix Cancer?
Scroll down to bottom of page for additional international listings of Pseudomyxoma Peritonei Treatments
Refer to the HIPEC page for additional information describing Pseudomyxoma Peritonei treatment
Don't forget to visit our Treatments, HIPEC, Surgery and Chemotherapy links!
Pseudomyxoma Peritonei Symptoms***
What are the symptoms of PMP?
Symptoms of the Pseudomyxoma Peritonei syndrome may include pain in the lower right quadrant, a feeling of "bloating", abdominal distension, digestive disturbances, loss of appetite, inability to eat a complete meal, constipation and/or diarrhea, shortness of breath, the "appearance" of a "hernia" or other vague symptoms.
Pseudomyxoma Peritonei Syndrome Symptom and Synonyms
Source: Quest Diagnostics
Pseudomyxoma Peritonei Syndrome Symptoms and Definition
Source: National Cancer Institute
Clinicopathologic Features of Pseudomyxoma Peritonei Syndrome and Mucinous Adenocarcinoma
Cancer Symptoms Solutions and Resources
Pseudomyxoma Peritonei Syndrome Diagnostics
What is the average age of diagnosis for PMP?
The average age of diagnosis for the Pseudomyxoma Peritonei syndrome is approximately 44 years old.
Accurate diagnosis may be confirmed through pathology, although cases can be suspected on the basis of symptoms, diagnostic imaging (CT scans) and laboratory tests (to a limited degree.)
Pseudomyxoma Peritonei Syndrome: Use of CT Images to Assess for Surgery,
Source: Journal Chirugie, France June 2009
Pseudomyxoma Peritonei Syndrome CT Images
Source: 2004
Pseudomyxoma Peritonei Syndrome CT Images
Source: MedPix 2009
Pseudomyxoma Peritonei Syndrome CT Diagnostics
Source: Bejing 2008
Pseudomyxoma Peritonei Syndrome Symptoms and Images
Source: MedTech 2009
Diagnostic Imaging of Pseudomyxoma Peritonei Syndrome
Source: Royal College of Radiologists 2003
Pseudomyxoma Peritonei Syndrome Rarely Diagnosed via Colonoscopy
Source: Wake Forest University 2009
Pseudomyxoma Peritonei Syndrome Features
Source: Royal Society of Medicine
Pseudomyxoma Peritonei Treatment Syndrome Data Base of Publications
Pseudomyxoma Peritonei Syndrome Study: Memorial Sloan Kettering
Source: Springerlink 2007
Pseudomyxoma Peritonei with Abdominal Calcifications CT Scans
Source: University of Tokyo, 1991
Additional resources describing diagnostic testing for Pseudomyxoma Peritonei are listed on our DIAGNOSTICS link and in our PMP Pals' Network Handbooks.
Pseudomyxoma Peritonei Pathology ****
Study of Pseudomyxoma Peritonei and Appendiceal Mucocele
Source: Service d/Anatomie et de Cytologic Pathologiques, 2007
Pathophysiology of Pseudomyxoma Peritonei and related conditions
Source: Dr H Muller, Germany
Histopathology: Study of Treatment of Pseudomyxoma Peritonei
Source: Dr Paul Sugarbaker, 2000
Pseudomyxoma Peritonei Syndrome Pathology Review
Source: Elsevier 2007
Pseudomyxoma Peritonei and Mucinous Adenocarcinoma Clinicopathologic Features: Study of 34 patients, Taiwan
Source: Digestive Surgery, 2008
Pseudomyxoma Peritonei Syndrome is a clonal disease
Source: ASCO
Pseudomyxoma Peritonei Treatment: DPAM
Annals of Surgical Oncology 1999
Pseudomyxoma Peritonei Syndrome Synonyms
Source: Labome 2009
Pseudomyxoma Peritonei Appendix Cancer Morphology (includes graphic color illustrations)
Source: Dr Paul Sugarbaker
Pseudomyxoma Peritonei Treatment Atlas of Appendix Cancer (includes graphic illustrations)
Source: Dr Paul Sugarbaker
Pseudomyxoma Peritonei Syndrome Genetic Factors
Reg4 Gene Coding for Pseudomyxoma Peritonei
MUC2 Gene Coding for Pseudomyxoma Peritonei
Pseudomyxoma Peritonei Syndrome Complications
Pseudomyxoma Peritonei and Sciatica
Source: Pub Med 2009
Pleural Pseudomyxoma Peritonei Treated with Thoracic CRS and HIPEC
Source: University of New South Wales, Austrailia, 2009
Appendix Cancer and Pseudomyxoma Peritonei Metastasis to the Stomach
Source: Springerlink, Japan, 2002
Pseudomyxoma Peritonei and Urachal Cyst
Source: Indian Journal of Urology 2008
Pseudomyxoma Peritonei and Renal Complications
Source: Indian Journal of Pathology and Microbiology, 2008
Peudomyxoma Peritonei Syndrome Metastases
Pseudomyxoma Peritonei Metastases to the Spleen
Pseudomyxoma Peritonei Pulmonary Metastases
Pseudomyxoma Peritonei Metastasis to Pleural Cavity
Pseudomyxoma Peritonei Originating with Appendix Cancer
Pseudomyxoma Peritonei Cox II Expression
Source: Dr Brian Loggie, Creighton University
Genomics of Metastasis
MedScape 2009
Pseudomyxoma Peritonei Syndrome OB/GYN
Some cases of Pseudomyxoma Peritonei originate with the ovaries.
Management of Pseudomyxoma Peritonei syndrome during pregnancy
Source: Dr Paul Sugarbaker, 2009
Pseudomyxoma Peritonei Syndrome discovered during Cesearean section
Source: University of Tennessee, 2009
Pseudomyxoma Peritonei Syndrome cystic teratoma of the Ovary
Source: University of Korea, Seoul 2009
Pseudomyxoma Peritonei syndrome orginating with the Ovary
Source: Gynecological Oncology, Japan, 2009
Pseudomyxoma Peritonei syndrome affects/contributes to infertility
Source: Albert Einstein University/Montefiore, NY, 2009
Pseudomyxoma Peritonei syndrome associated with ovarian mestastasis
Source: Korea University 2009
Pseudomyxoma Peritonei syndrome and HPV originating with the Cervix
Source: Croatian Journal of Medicine, 2008
Pathology of Ovarian Cancers
Source: Dr Brigitte Ronnett
Mucinous Cystadenoma,***** Pseudomyxoma Peritonei
Mucinous Cystadenoma and Appendix Cancer Carcinoid
Source: Journal of Medical Care 2009
Mucinous Cystadenoma of the Appendix
Source: Prince of Wales Hospital, Hong Kong, 2009
Complications from Mucinous Cystadenoma
International References for Pseudomyxoma Peritonei Treatments and Research
Australia
Pseudomyxoma Peritonei Prognosis Long Term Survival (10 year study)
Source: Annals of Surgical Oncology, 2009, Prof David L Morris, St George Hospital
Belgium
Cytoreductive Surgery and HIPEC for Pseudomyxoma Peritonei Treatment at Leopold Park Clinic, Brussels
Source: Dr Stefaan Mulier
Canada
Appendix Cancer and Pseudomyxoma Peritonei treatment with CRS and HIPEC
Source: Universite de Montreal 2009
China
Finland
Pseudomyxoma Peritonei Prognosis following serial debulking (long term study)
Source: Helskinki Univ Central Hospital, Finland, June 2009
Holland/Nederland
Pseudomyxoma Peritonei Treatment with Cytoreductive Surgery and HIPEC in Holland
Italy/Italia
Pseudomyxoma Peritonei Prognosis Determinants following (CRS)Cytoreductive Surgery and HIPEC
Source: Pub Med via National Cancer Institute of Milan, Italy 2009
Japan
Treatment of Pseudomyxoma Peritonei and Appendix Cancer
Source: International Journal of Oncology 2009
Pseudomyxoma Peritonei Prognosis following Chemo Hyperthermic Profusion
Source: Fukai School of Medicine, Japan, April 2009
United Kingdom
Phase II Study Tests Effectiveness of Systemic Chemo for Pseudomyxoma Peritonei
Source: Christies Hospital, Manchester UK, Aug 2008
United States
US Congress Approves $24 Million to Study Rare Diseases Including Pseudomyxoma Peritonei
Source: Reuters, May 2009
Evaluation of Surgery for Pseudomyxoma Peritonei Treatment
Dr Martin Goodman Provides Pseudomyxoma Peritonei HIPEC Treatment
Source: Tufts University, Boston
Dr Perry Shen Provides HIPEC Pseudomyxoma Peritonei Treatment
Source: Wake Forest University
Dr David L Bartlett, Dr James Pingpank, Dr Steven Ahrendt provide Pseudomyxoma Peritonei Treatment
Source: Koch Cancer Treatment Center, UPMC
Prognosis following Pseudomyxoma Peritonei Treatment
Source: Mayo Clinic
Pseudomyxoma Peritonei Treatment and, Appendix Cancer: Steps to Prepare for Surgery
Source: Mercy Medical Center
Pseudomyxoma Peritonei Treatment, Appendix Cancer Surgical Treatment
Source: Moores Cancer Center UCSD
Surgical Treatment for Pseudomyxoma Peritonei Treatment, Appendix Cancer, Peritoneal Carcinomatosis
Source: St Agnes Hospital
Pseudomyxoma Peritonei Treatment:“Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy
Source: Dr Paul F Mansfield,Annals of Surgical Oncology 2007
Pseudomyxoma Peritonei Treatment "Second Look Surgery" Study of 312 Patients
Source: Dr Paul Sugarbaker, Washington Hospital Center, 2000
Cytoreductive Surgery for Pseudomyxoma Peritonei Treatment, Appendix Cancer, Peritoneal Carcinomatosis
(includes graphic illustrations)
Source: Dr Paul Sugarbaker
Pseudomyxoma Peritonei Treatment "Second Look Surgery"
Source: Modern Pathology, Dr Paul Sugarbaker
Hyperthermia Pseudomyxoma Peritonei Treatment
Source: Springerlink 2006
Malignant Mesothelioma
See also CLINICAL TRIALS
Mesothelioma Treatment: Safety of Gastric Resection with Cytoreductive Surgery and HIPEC
Source: Annals of Surgical Oncology, Prof P Piso
Malignant Mesothelioma is a challenging diagnosis
Source: Reuters 2009
Malignant Pleural Mesothelioma
Source: MedScape 2009
Pathophysiology of Mesothelioma
Source: Dr H Muller,Germany
Peritoneal Mesothelioma
Mesolthelioma Gene Test
Source: Reuters 2009
