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                                                                                                                                                                  Pseudomyxoma Peritonei Long Term Survival and Prognosis

                                                                                                                                                                  Study of 2300 PMP Cases: Long Term Survival

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                                                                                                                                                                  An international array of surgical oncology researchers, including Terence C. Chua, Brendan J. Moran, Paul H. Sugarbaker, Edward Allen Levine, Olivier Glehen, Francois N. Gilly, Dominique Elias, Dario Baratti, Marcello Deraco, Armando Sardi, David L. Morris, established a multi institutional registry in affiliation with the Peritoneal Surface Oncology Group International (PSOGI) to study the effects of CRS and HIPEC on nearly 2,300 Pseudomyxoma Peritonei patients.

                                                                                                                                                                  “The median survival was 196 months or 16.3 years. The median progression-free survival (PFS) was 98 months or 8.2 years, with a 10- and 15-year survival rate of 63% and 59% respectively.”

                                                                                                                                                                  Click here to review the abstract from this collaborative effort.



                                                                                                                                                                  Presented at ASCO, 01.20.12

                                                                                                                                                                  PMP Pals' Network: Resources, Referrals, Research and Support!

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                                                                                                                                                                  Ken lives an active life following treatment for Appendiceal Cancer with Pseudomyxoma Peritonei Syndrome!

                                                                                                                                                                  Become a "PMP Pal" and communicate directly with Ken!


                                                                                                                                                                  This week's article of interest...


                                                                                                                                                                  Cancer Survivors: A Booming Population

                                                                                                                                                                  This abstract focuses on the growing number of survivors and population aging, and the impact these combined trends will have on cancer survivorship in the future.

                                                                                                                                                                  Source:     Julia H. Rowland, National Cancer Institute/NIH, Office of Cancer Survivorship, Division of Cancer Control and Population Sciences, 6116 Executive Boulevard, Suite 404, Bethesda, MD 20892. Phone: 301-402-2746; Fax: 301-594-5070; E-mail: rowlandj@mail.nih.gov

                                                                                                                                                                  Pseudomyxoma Peritonei Prognosis and Long Term Survival Rate

                                                                                                                                                                  What is the long term prognosis for Pseudomyxoma Peritonei?

                                                                                                                                                                  The doctor says I have "PMP." What is my prognosis?

                                                                                                                                                                  What is the prognosis for "PMP?"

                                                                                                                                                                  What are the long term survival statistics for Pseudomyxoma Peritonei?

                                                                                                                                                                  What is the long term survival rate for Pseudomyxoma Peritonei?


                                                                                                                                                                  Can I outlive the survival statistics for Pseudomyxoma Peritonei?


                                                                                                                                                                  The prognosis and survival for Pseudomyxoma Peritonei, and Appendiceal Cancer , in general, has improved during the past decade, with earlier detection, enhanced education of healthcare providers, including radiologists and pathologists, followed by referrals to specialists and improved methods of treatment.

                                                                                                                                                                  Many factors contribute to the prognosis and long term survival of patients. These factors may include pathology, staging at the time of diagnosis, overall health of the patient at the time of the diagnosis, age at the time of diagnosis,  access to specialized care, etc.


                                                                                                                                                                  Long term survival may increase with early and accurate diagnosis, overall health of the patient at the time of diagnosis, the actual pathology/diagnosis itself, and appropriate treatment provided by a specialist.


                                                                                                                                                                  Patients are encouraged not to accept the original dismal prognosis that may initially be offered by a non specialist.

                                                                                                                                                                  Each case is unique and each patient is an individual. Published statistics do not reflect the unique case of a newly diagnosed patient, whose options for long term survival are continually improving through modern medical treatment.

                                                                                                                                                                  Communicate with any of our Pal Mentors who have been disease free from five to twenty years!

                                                                                                                                                                  One patient's story of hope!

                                                                                                                                                                  Read articles about our cancer free "Pals!"

                                                                                                                                                                  Read "Cancer Patients Can Outlive Statistics" by PMP Pals

                                                                                                                                                                  Read survival stories from our fellow "Pals!"

                                                                                                                                                                  This week's featured medical report:


                                                                                                                                                                  Upfront Compared to Delayed Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei Is Associated With Considerably Lower Perioperative Morbidity and Recurrence Rate.
                                                                                                                                                                  Chua TC, Liauw W, Zhao J, Morris DL.

                                                                                                                                                                  *UNSW Department of Surgery, St George Hospital, Kogarah, Sydney, Australia. †Department of Medical Oncology, Cancer Care Centre, St George Hospital, Kogarah, Sydney, Australia.

                                                                                                                                                                  Abstract

                                                                                                                                                                  BACKGROUND: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) is a recognized management strategy for pseudomyxoma peritonei. We seek to evaluate the outcomes of patients treated upfront with CRS PIC compared to patients undergoing delayed CRS PIC as salvage or treatment for recurrences after initial debulking surgery.

                                                                                                                                                                  METHODS: Retrospective analysis of patients with low-grade pseudomyxoma peritonei treated within our institution were stratified according to upfront versus delayed CRS PIC after intial debulking surgery. Survival was analyzed using the Kaplan-Meier method and compared using the log-rank test.

                                                                                                                                                                  RESULTS: Of 83 patients treated, 35 patients (42%) underwent upfront and 48 patients (58%) underwent delayed CRS PIC. The peritoneal cancer index (P = 0.048), amount of blood transfusion intraoperatively (P = 0.003) and duration of operation (P = 0.007) was lesser in the upfront compared to delayed group. Upfront treatment confers 5-year recurrence-free survival benefit (77% vs 37%; P = 0.011) and 10-year overall survival benefit (67% vs 35%; P = 0.054) over delayed treatment.

                                                                                                                                                                  CONCLUSION:
                                                                                                                                                                  Upfront CRS PIC seems to confer beneficial perioperative outcomes and lower recurrence rates over delayed CRS PIC. Early referral to centralized treatment centers would seem to be a reasonable strategy to improve outcomes. Source: Annals of Surgical Oncology, Jan 13, 2011

                                                                                                                                                                  Here are a selection of medical journal excerpts and reports providing specific details about the prognosis and long term survival statistics for Pseudomyxoma Peritonei.
                                                                                                                                                                  Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: a multi-institutional study of 1290 patients.
                                                                                                                                                                  Glehen O, Gilly FN, Boutitie F, Bereder JM, Quenet F, Sideris L, Mansvelt B, Lorimier G, Msika S, Elias D; the French Surgical Association.
                                                                                                                                                                  Cancer. 2010 Aug 24. [Epub ahead of print]PMID: 20737573 [PubMed - as supplied by publisher]
                                                                                                                                                                  Secondary Cytoreduction and Perioperative Intraperitoneal Chemotherapy after Initial Debulking of Pseudomyxoma Peritonei: A Study of Timing and the Impact of Malignant Dedifferentiation.

                                                                                                                                                                  Chua TC, Al-Zahrani A, Saxena A, Liauw W, Zhao J, Morris DL.
                                                                                                                                                                  J Am Coll Surg. 2010 Aug 20. [Epub ahead of print]PMID: 20729102 [PubMed - as supplied by publisher]
                                                                                                                                                                  [Prospective study of quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy using oxaliplatin for peritoneal carcinomatosis.]

                                                                                                                                                                  Lim C, Tordjmann D, Gornet JM, Nemeth J, Valleur P, Pocard M.
                                                                                                                                                                  Bull Cancer. 2010 Aug 6. [Epub ahead of print] French. PMID: 20693116 [PubMed - as supplied by publisher]Related citations
                                                                                                                                                                  The second procedure combining complete cytoreductive surgery and intraperitoneal chemotherapy for isolated peritoneal recurrence: postoperative course and long-term outcome.

                                                                                                                                                                  Brouquet A, Goéré D, Lefèvre JH, Bonnet S, Dumont F, Raynard B, Elias D.
                                                                                                                                                                  Ann Surg Oncol. 2009 Oct;16(10):2744-51. Epub 2009 Jul 21.PMID: 19626375 [PubMed - indexed for MEDLINE]Related citations
                                                                                                                                                                  Survival of patients with pseudomyxoma peritonei treated by serial debulking.

                                                                                                                                                                  Järvinen P, Järvinen HJ, Lepistö A.
                                                                                                                                                                  Colorectal Dis. 2010 Sep;12(9):868-72. Epub 2009 Jun 10.PMID: 19519686 [PubMed - in process]Related citations
                                                                                                                                                                  .Long-term survival in patients with pseudomyxoma peritonei treated with cytoreductive surgery and perioperative intraperitoneal chemotherapy: 10 years of experience from a single institution.

                                                                                                                                                                  Chua TC, Yan TD, Smigielski ME, Zhu KJ, Ng KM, Zhao J, Morris DL.
                                                                                                                                                                  Ann Surg Oncol. 2009 Jul;16(7):1903-11. Epub 2009 Apr 23.PMID: 19387742 [PubMed - indexed for MEDLINE]Related citations
                                                                                                                                                                  Pseudomyxoma peritonei: biological features are the dominant prognostic determinants after complete cytoreduction and hyperthermic intraperitoneal chemotherapy.

                                                                                                                                                                  Baratti D, Kusamura S, Nonaka D, Cabras AD, Laterza B, Deraco M.
                                                                                                                                                                  Ann Surg. 2009 Feb;249(2):243-9.PMID: 19212177 [PubMed - indexed for MEDLINE]Related citations
                                                                                                                                                                  Thoracic cytoreductive surgery and intraoperative hyperthermic intrathoracic chemotherapy for pseudomyxoma peritonei.
                                                                                                                                                                  Chua TC, Yan TD, Yap ZL, Horton MD, Fermanis GG, Morris DL.

                                                                                                                                                                  J Surg Oncol. 2009 Apr 1;99(5):292-5.PMID: 19180588 [PubMed - indexed for MEDLINE]Related citations

                                                                                                                                                                  Preoperative performance status predicts outcome following heated intraperitoneal chemotherapy.

                                                                                                                                                                  Reuter NP, Macgregor JM, Woodall CE, Sticca RP, William C, Helm MB, Scoggins CR, McMasters KM, Martin RC.
                                                                                                                                                                  Am J Surg. 2008 Dec;196(6):909-13; discussion 913-4.PMID: 19095108 [PubMed - indexed for MEDLINE]Related citations
                                                                                                                                                                  Consensus statement on the loco-regional treatment of appendiceal mucinous neoplasms with peritoneal dissemination (pseudomyxoma peritonei).

                                                                                                                                                                  Moran B, Baratti D, Yan TD, Kusamura S, Deraco M.
                                                                                                                                                                  J Surg Oncol. 2008 Sep 15;98(4):277-82. Review.PMID: 18726894 [PubMed - indexed for MEDLINE]Related citations

                                                                                                                                                                  Pseudomyxoma Peritonei Long Term Survival (10 year study)

                                                                                                                                                                  Source: Annals of Surgical Oncology, 2009, Prof David L Morris, St George Hospital,Univ of New South Wales, Sydney, AU
                                                                                                                                                                  This report describes the long-term survival in patients with pseudomyxoma peritonei treated with cytoreductive surgery and perioperative intraperitoneal chemotherapy: 10 years of experience.  This report demonstrates long-term survival outcomes, acceptable perioperative outcomes, and a learning curve associated with the treatment of patients with pseudomyxoma peritonei.


                                                                                                                                                                  Pseudomyxoma Peritonei

                                                                                                                                                                  Biological Features Are the Dominant Prognostic Determinants After Complete Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy
                                                                                                                                                                  Source: Annals of Surgery, Dr Marcello Deraco, Dr Baratti, 2009

                                                                                                                                                                  Morbidity and Mortality: Study of HIPEC and CRS for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgery, Feb 2009, Dr David Morris, Dr Tristan Yan


                                                                                                                                                                  Conclusions: The morbidity and mortality outcomes of CRS and HIPEC are similar to a major gastrointestinal surgery, such as a Whipple's procedure. To derive the maximal benefit of this treatment, careful patient selection with an optimal level of postoperative care must be advocated to avoid undesirable complications of this treatment.

                                                                                                                                                                  DPAM: Peritonectomy Improves Survival
                                                                                                                                                                  Source Prof David L Morris, 2009


                                                                                                                                                                  12 Year Study of CRS and HIPEC for Pseudomyxoma Peritonei Treatment
                                                                                                                                                                  Source: In Vivo, 2009


                                                                                                                                                                  DPAM Long Term Survival
                                                                                                                                                                  Source: Dr BM Ronnett, Dr Paul H Sugarbaker, 2009

                                                                                                                                                                  Pseudomyxoma Peritonei Long Term Survival (10 year study) 
                                                                                                                                                                  Source: Annals of Surgical Oncology, 2009, Prof David L Morris, St George Hospital

                                                                                                                                                                  Appendiceal Mucinous Neoplasms: Study Analysis Predicting Recurrance
                                                                                                                                                                  Source: American Journal of Surgical Pathology, 2009

                                                                                                                                                                  CRS with HIPEC have improved quality and quantity of life for patients
                                                                                                                                                                  Source:Dr Brian Loggie, 2007


                                                                                                                                                                  Survival Study for Pseudomyxoma Peritonei: DPAM, PMCA, PMCA 1
                                                                                                                                                                  Source: Dr Edward Levine, American Journal of Surgical Pathology, May 2006

                                                                                                                                                                  Appendix Cancer Prognosis
                                                                                                                                                                  Source: Dr Paul Sugarbaker, Washington Hospital Center

                                                                                                                                                                  Appendiceal Adenocarcinoma: Long Term Outcome After Surgery
                                                                                                                                                                  Source: Harvard Medical School, 2004

                                                                                                                                                                  Morbidity and Mortality Study for Pseudomyxoma Peritonei following CRS and HIPEC
                                                                                                                                                                  Source: Pseudomyxoma Peritonei Center, Hampshire, June 2009
                                                                                                                                                                   
                                                                                                                                                                  Pseudomyxoma Peritonei Prognosis following serial debulking (long term study)
                                                                                                                                                                  Source: Helskinki Univ Central Hospital, Finland, June 2009


                                                                                                                                                                  Pseudomyxoma Peritonei Prognosis for VEGH  expression patients with Mucinous Adenocarcinoma of the Appendix
                                                                                                                                                                  Source: Annals of Surgical Oncology 2008


                                                                                                                                                                  Pseudomyxoma Peritonei Prognosis following Chemo Hyperthermic Profusion
                                                                                                                                                                  Source: Fukai School of Medicine, Japan, April 2009


                                                                                                                                                                  Pseudomyxoma Peritonei prognosis: biologic features affecting prognosis
                                                                                                                                                                  Source: Annals of Surgical Oncology 2009


                                                                                                                                                                  Pseudomyxoma Peritonei prognosis and survival  following surgery and HIPEC
                                                                                                                                                                  Source: Pub Med, Feb 2009


                                                                                                                                                                  Pseudomyxoma Peritonei prognosis and survival evaluating tumor markers following surgery and HIPEC
                                                                                                                                                                  Source: Annals of Surgical Oncology, 2008


                                                                                                                                                                  Pseudomyxoma Peritonei prognosis  following HIPEC treatment
                                                                                                                                                                  Source: ASCO 2007


                                                                                                                                                                  Pseudomyxoma Peritonei and Peritonei Carcinomatosis Prognosis Indicators
                                                                                                                                                                  Source: Pub Med 2005


                                                                                                                                                                  Pseudomyxoma Peritonei Treatment: Library of Medical Publications
                                                                                                                                                                  Source: Pub Med 2009


                                                                                                                                                                  Appendix Cancer Library including Pseudomyxoma Peritonei Treatment and Prognosis: Multiple Medical Publications
                                                                                                                                                                  Source: Pub Med 2009


                                                                                                                                                                  Analysis of 46 Pseudomyxoma Peritonei patients' prognosis following "second look" surgery
                                                                                                                                                                  Source: Dr Paul Sugarbaker 2000

                                                                                                                                                                  Cancer Survivorship
                                                                                                                                                                  The Survivors' Club
                                                                                                                                                                  Source: Ben Sherwood, author

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