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                                                                                                                                                                  Alphabetical Index of Articles by Appendix Cancer, Colorectal Cancer and Pseudomyxoma Peritonei Treatment Specialists

                                                                                                                                                                  Picture

                                                                                                                                                                  Click here for names and contact info for surgeons and specialists.


                                                                                                                                                                  We provide the following listing of abstracts and articles, published by, and/or written about the world's most experienced international surgeons and specialists in the treatment and research of Pseudomyxoma Peritonei, and Appendix Cancer. The full titles of some abstracts have been abbreviated due to space limitations.
                                                                                                                                                                   
                                                                                                                                                                  Alpha listings by surname:

                                                                                                                                                                  Articles by Dr Syed Ahmad, USA

                                                                                                                                                                  Title: VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon.

                                                                                                                                                                  Abstract

                                                                                                                                                                  BACKGROUND: High levels of vascular endothelial growth factor (VEGF) in ovarian cancer metastases are associated with a worse prognosis in patients treated with chemotherapy. VEGF-directed therapy improves survival for those with metastatic colorectal cancer. Patients with mucinous adenocarcinomas metastatic to the peritoneal surfaces can be treated with cytoreductive surgery, and both tumor grade and cytoreduction status are prognostic. We hypothesized that angiogenic indices may be prognostic in patients undergoing cytoreductive surgery for mucinous adenocarcinoma of the appendix and colon.

                                                                                                                                                                  METHODS: Cytoreductive cases from a 5-year period from the University of Cincinnati peritoneal malignancy database were reviewed. CD 34 counts (blood vessels) and VEGF expression was evaluated by means of immunohistochemistry on specimens from patients undergoing cytoreductive surgery and intraperitoneal hyperthermic perfusion (IPHP) for mucinous adenocarcinoma.

                                                                                                                                                                  RESULTS: A total of 26 males and 9 females, with a mean age of 50 years, underwent cytoreductive surgery and IPHP for mucinous adenocarcinoma of appendiceal (n = 32) or colonic (n = 3) origin. With a mean follow-up of 18 months (range 1-63 months), 23 had disease recurrence and 12 were alive without recurrence. The mean survival was 19 months (range 1-63 months). CD34 counts did not correlate with recurrence or survival; however, average VEGF counts correlated with survival (P = 0.017), and, for patients with recurrence, this correlation was stronger (P = 0.002).

                                                                                                                                                                  CONCLUSIONS: These results suggest that markers of tumor angiogenesis may predict survival in patients with peritoneal surface metastases from mucinous adenocarcinoma. These findings provoke the hypothesis that antiangiogenic therapies may be effective in patients with this devastating disease.

                                                                                                                                                                  Source:Ann Surg Oncol. 2008 Mar;15(3):738-44. Epub 2007 Nov 28.

                                                                                                                                                                  Current  concepts in the surgical management of pancreatic cancer
                                                                                                                                                                  Source: Surg Oncol Clin N Am. 2010 Apr;19(2):335-58. Review.PMID: 20159518

                                                                                                                                                                  Articles by Dr SA Ahrendt, USA

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients
                                                                                                                                                                  Source: Journal of Clinical Oncology 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgical Oncology, 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Colorectal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgical Oncology, Nov 2008

                                                                                                                                                                  Articles by Dr Fernando Arias, Colombia

                                                                                                                                                                  Sleeve Gastrectomy
                                                                                                                                                                  Source: Fundacion Santa Fe de Bogota


                                                                                                                                                                  Abstracts by Dr Mario Baratti, Italy

                                                                                                                                                                  Pseudomyxoma PeritoneiBiological Features Are the Dominant Prognostic Determinants After Complete Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy
                                                                                                                                                                  Source: Annals of Surgery, Dr Marcello Deraco, Dr Baratti, 2009


                                                                                                                                                                  Articles by Dr David L Bartlett, USA

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients
                                                                                                                                                                  Source: Journal of Clinical Oncology 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Anuals of Surgical Oncology, 2008

                                                                                                                                                                  HIPEC: The Complexity of Clinical Trials
                                                                                                                                                                  Source: Dr David L Bartlett, UPMC, Society of Surgical Oncology 2008

                                                                                                                                                                  Dr David L Bartlett, Dr James Pingpank, Dr Steven Ahrendt
                                                                                                                                                                  Source: Koch Cancer Treatment Center, UPMC

                                                                                                                                                                  Profile for Dr David L Bartlett
                                                                                                                                                                  Source: UPMC

                                                                                                                                                                  Dr David L Bartlett:
                                                                                                                                                                  Koch Cancer Center
                                                                                                                                                                  Source: UPMC

                                                                                                                                                                  Dr David L Bartlett: Treatment of Liver Cancer
                                                                                                                                                                  Source: UPMC Koch Cancer Center

                                                                                                                                                                  Articles by Dr Jean Bereder, France

                                                                                                                                                                  Study of 300+ Patients Treated with CRS and PIC
                                                                                                                                                                  Abstract of a study of 300+ Pseudomyxoma Peritonei patients treated with cytoreductive surgery and intraperitoneal chemotherapy. Describes "gold standard " of treatment.
                                                                                                                                                                   
                                                                                                                                                                  Source: Elias D, Gilly F, Quenet F, Bereder JM, Sidéris L, Mansvelt B, Lorimier G, Glehen O; the Association Française de Chirurgie.
                                                                                                                                                                  Department of Oncologic Surgery, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif Cédex, France March 2010

                                                                                                                                                                  Study of 523 Colorectal Peritoneal Carcinomatosis Cases: CRS and IPC
                                                                                                                                                                  Source: Journal of Clinical Oncology,2010

                                                                                                                                                                  Articles by Dr Wim Ceelen, Belgium

                                                                                                                                                                  Dr Wim P Ceelen treats Pseudomyxoma Peritonei with HIPEC www.surgery.ugent.be

                                                                                                                                                                  Articles by Dr Marcello Deraco, Italy

                                                                                                                                                                  Pseudomyxoma PeritoneiBiological Features Are the Dominant Prognostic Determinants After Complete Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy
                                                                                                                                                                  Source: Annals of Surgery, Dr Marcello Deraco, Dr Baratti, 2009


                                                                                                                                                                  HIPEC Treatment: Dott. Marcello Deraco: Pseudomyxoma Peritonei and Appendix Cancer
                                                                                                                                                                  Source: Dott. Marcello Deraco

                                                                                                                                                                  Articles by Dr D Elias, France

                                                                                                                                                                  Study of 523 Colorectal Peritoneal Carcinomatosis Cases: CRS and IPC
                                                                                                                                                                  Source: Journal of Clinical Oncology,2010

                                                                                                                                                                  Articles by Dr Jesus Esquivel, USA

                                                                                                                                                                  Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients with Limited Peritoneal Surface Malignancies: Feasibility, Morbidity and Outcome in an Early Experience.

                                                                                                                                                                  Laparoscopic CRS and HIPEC in Patients with Limited PSMs

                                                                                                                                                                  Source: Esquivel J, Averbach A, Chua TC  St. Agnes Hospital, Baltimore, Maryland.

                                                                                                                                                                  Ann Surg. 2011 Jan 6. [Epub ahead of print]

                                                                                                                                                                  Abstract

                                                                                                                                                                  INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are being widely used in the treatment of patients with peritoneal surface malignancies. The open procedure has been associated with high grade III and IV morbidity and prolonged hospitalization.

                                                                                                                                                                  METHODS: Patients with peritoneal surface malignancies and no gross evidence of carcinomatosis on the computed tomographic scan were enrolled to undergo laparoscopic CRS and HIPEC. We aimed to assess the feasibility, safety, and outcome of this procedure. Postoperative complications were reported according to the National Cancer Institute Common Toxicity Criteria.

                                                                                                                                                                  RESULTS: From October 2008 to January 2010, 14 patients were enrolled into the protocol. Amongst these 14 patients, one patient was found with extensive carcinomatosis at the time of laparoscopy and had no surgical procedure. Thirteen patients had a complete cytoreduction and HIPEC, 10 (77%) laparoscopically and 3 (23%) were converted to an open procedure. There was one grade 3 morbidity (10%) and one patient (10%) in the laparoscopy group experienced a grade 4 complication, needing a reoperation for an internal hernia. Mean length of hospital stay was 6 days for those completed laparoscopically, 8 days for those converted to an open procedure and 8 days for a matched cohort of patients with an upfront open procedure.

                                                                                                                                                                  CONCLUSIONS: This initial investigative stage demonstrates the feasibility and safety of cytoreductive surgery and HIPEC via the laparoscopic route in selected patients with low-tumor volume and no small bowel involvement mainly from appendiceal malignancies. Longer follow-up and additional studies are required to evaluate its long-term efficacy.

                                                                                                                                                                  PMID: 21217512 [PubMed - as supplied by publisher]


                                                                                                                                                                  Learning Curve for CRS and HIPEC
                                                                                                                                                                  Source: Journal of Surgical Oncology, August 2009


                                                                                                                                                                  Laparoscopic CRS and HIPEC Treatment for Peritoneal Mesothelioma
                                                                                                                                                                  Source: Dr Jesus Esquivel, 2009

                                                                                                                                                                  HIPEC Treatment available at St Agnes Hospital
                                                                                                                                                                  Source: Dr Jesus Esquivel

                                                                                                                                                                  Pros and Cons of HIPEC: Dr Jesus Esquivel
                                                                                                                                                                  Source: Oncology Times, Jan 2007

                                                                                                                                                                  Physician Profile for Dr Jesus Esquivel
                                                                                                                                                                  Source: St Agnes Hospital

                                                                                                                                                                  Dr Jesus Esquivel:
                                                                                                                                                                  St Agnes Hospital
                                                                                                                                                                  Source: St Agnes Hospital

                                                                                                                                                                  Articles by Dr Jan Franko, USA

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients
                                                                                                                                                                  Source: Journal of Clinical Oncology 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgical Oncology, 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Colorectal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgial Oncology, Nov 2008

                                                                                                                                                                  Click here to read Dr Jan Franko's profile

                                                                                                                                                                  Articles by Dr Gilly, France

                                                                                                                                                                  Study of 300+ Patients Treated with CRS and PIC :
                                                                                                                                                                  Abstract of a study of 300+ Pseudomyxoma Peritonei patients treated with cytoreductive surgery and intraperitoneal chemotherapy. Describes "gold standard " of treatment.
                                                                                                                                                                   
                                                                                                                                                                  Source: Elias D, Gilly F, Quenet F, Bereder JM, Sidéris L, Mansvelt B, Lorimier G, Glehen O; the Association Française de Chirurgie.
                                                                                                                                                                  Department of Oncologic Surgery, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif Cédex, France March 2010

                                                                                                                                                                  Study of 523 Colorectal Peritoneal Carcinomatosis Cases: CRS and IPC
                                                                                                                                                                  Source: Journal of Clinical Oncology,2010

                                                                                                                                                                  Articles by Dr Matthew Holtzman, USA

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients
                                                                                                                                                                  Source: Journal of Clinical Oncology 2008

                                                                                                                                                                  Articles by Dr Joachim Jaehne, Germany

                                                                                                                                                                  Cytoreductive Surgery Techniques
                                                                                                                                                                  Source: Dr Joachim Jaehne, August 2009, Wiley


                                                                                                                                                                  CRS:Stategies to Reduce Post Op Morbidity and Complications
                                                                                                                                                                  Source: Dr Joachim Jaehne, April 2009


                                                                                                                                                                  Articles by Dr Santiago Gonzalez-Moreno, Spain

                                                                                                                                                                  Patient Selection for CRS and HIPEC
                                                                                                                                                                  Source: Journal of Surgical Oncology 2009

                                                                                                                                                                  Articles by Dr Martin Goodman, USA

                                                                                                                                                                  Dr Martin Goodman at Tufts University provides HIPEC
                                                                                                                                                                  Source: Tufts University, Boston

                                                                                                                                                                  Articles by Dr Matthew Holtzman, USA

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgical Oncology, 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Colorectal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgial Oncology, Nov 2008

                                                                                                                                                                  Articles by Dr Daniel Labow, USA


                                                                                                                                                                  Sarpel U, Bonavia AS, Grucela A, Roayaie S, Schwartz ME, Labow DM. Does Anatomic Versus Nonanatomic Resection Affect Recurrence and Survival in Patients Undergoing Surgery for Colorectal Liver Metastasis?. Annals of Surgical Onology 2008;.
                                                                                                                                                                  Konstadoulakis MM, Roayaie S, Gomatos IP, Labow D, Fiel MI, Miller CM, Schwartz ME. Fifteen-year, single-center experience with the surgical management of intrahepatic cholangiocarcinoma: operative results and long-term outcome. Surgery 2008; 143(3): 366-374.

                                                                                                                                                                  Cho CS, Labow DM, Gonen M, Jarnagin WR, D'Angelica M, Blumgart L, DeMatteo RP. Impact of Extent of Hepatic Resection for Metastatic Neuroendocrine Carcinoma. Cancer 2008 Jul 1; 113(1): 126-134.

                                                                                                                                                                  Labow DM, Buell JF, Yoshida A, Rosen S, Posner MC. Isolated pulmonary recurrence after resection of colorectal hepatic metastases--is resection indicated?. Cancer J 8 2002; 8(4): 342-347.

                                                                                                                                                                  Kammula US, Buell JF, Labow DM, Rosen S, Millis JM, Posner MC. Surgical management of benign tumors of the liver. Int J Gastrointest Cancer 2001; 30(3): 141-146.

                                                                                                                                                                  Conlon KC, Labow D, Smith A, Jarnagin W, Coit DG, Merchant N, Brennan MF. A prospective randomized clinical trial of the value of intra-peritoneal drainage following pancreatic resection. Annals of Surgery 2001; 234(4): 487-494.

                                                                                                                                                                  Kaneda Y, Liu D, Brooks A, Abolhoda A, Labow D, Burt ME, Ginsberg RJ. Toxicity and pharmacokinetics of isolated lung perfusion with cisplatin in rat. Japan Journal of Thoracic and Cardiovascular Surgery 2001; 49(7): 443-448.

                                                                                                                                                                  Buell JF, Rosen S, Yoshida A, Labow D, Limsrichamrern S, Cronin DC, Bruce DS, Wen M, Michelassi F, Millis JM, Posner MC. Hepatic resection: effective treatment for primary and secondary tumors. Surgery 2000; 128(4): 686-693.

                                                                                                                                                                  Labow D, Lee S, Ginsberg RJ, Crystal RG, Korst RJ. Adenovirus vector-mediated gene transfer to regional lymph nodes. Human Gene Therapy 2000; 11(5): 759-769.

                                                                                                                                                                  Labow DM, Brennan MF. Gastric Cancer. In: Bayless , Diehl , editors. Advanced Therapy in Gastroenterology and Liver Disease 5/e. BC Decker Inc;.

                                                                                                                                                                  Articles by Dr Laura Lambert, USA

                                                                                                                                                                  CRS and Perioperative Intraperitoneal Chemotherapy for Colorectal Carcinomatosis:
                                                                                                                                                                  Source: Annals of Surgical Oncology. 2007, Lambert, Laura A. and Paul F. Mansfield. 
                                                                                                                                                                  See:
                                                                                                                                                                  http://www.annalssurgicaloncology.org/cgi/content/full/14/11/3037


                                                                                                                                                                  Articles by Dr Edward Levine, USA

                                                                                                                                                                  CRS and HIPEC for the Treatment of Peritoneal Dissemination of Appendiceal and Colorectal Neoplasms
                                                                                                                                                                  Source: Dr Edward Levine, ASCO 2008

                                                                                                                                                                  “Appendiceal Carcinoma with Peritoneal Dissemination: Outcomes for the Best of the Best.” 
                                                                                                                                                                  Source: Annals of Surgical
                                                                                                                                                                  Oncology,2007, Dr Edward Levine, WFU

                                                                                                                                                                  Survival Study for Pseudomyxoma Peritonei: DPAM, PMCA, PMCA 1
                                                                                                                                                                  Source: Dr Edward Levine, American Journal of Surgical Pathology, May 2006

                                                                                                                                                                  DPAM and HIPEC Treatment
                                                                                                                                                                  Source: Wake Forest University


                                                                                                                                                                  Articles by Dr Brian W Loggie, USA

                                                                                                                                                                  CRS with HIPEC have improved quality and quantity of life for patients
                                                                                                                                                                  Source:Dr Brian Loggie, 2007

                                                                                                                                                                  Cox II expression in patients with Pseudomyxoma Peritonei and Disseminated Peritoneal Adenomucinosis
                                                                                                                                                                  Source: Dr Brian Loggie


                                                                                                                                                                  Gelatinous Ascites
                                                                                                                                                                  : A Cytohistologic Study of Pseudomyxoma Peritonei in 67 Patients


                                                                                                                                                                  Articles referring to Dr Brian Loggie's patients
                                                                                                                                                                  Source: PMP Pals' Network


                                                                                                                                                                  Articles by Dr Andrew Lowy, USA

                                                                                                                                                                  Minimally Invasive Laparoscopic Surgery
                                                                                                                                                                  Source: UCSD, Dr Andrew Lowy, 2009


                                                                                                                                                                  Dr Andrew Lowy: Moores Cancer Center
                                                                                                                                                                  Source: UCSD

                                                                                                                                                                  Treatment of Pancreatic Cancer
                                                                                                                                                                  Source: Dr Andrew Lowy UCSD

                                                                                                                                                                  VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon.Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA.           Source:Ann Surg Oncol. 2008 Mar;15(3):738-44. Epub 2007 Nov 28.

                                                                                                                                                                  Articles by Dr Paul Mansfield, USA

                                                                                                                                                                  Profile for Dr Paul Mansfield
                                                                                                                                                                  Source: MD Anderson

                                                                                                                                                                  CRS and HIPEC for the Treatment of Peritoneal Dissemination of Appendiceal and Colorectal Neoplasms

                                                                                                                                                                  Source: Dr Paul Mansfield, ASCO 2008

                                                                                                                                                                  CRS and Perioperative Intraperitoneal Chemotherapy for Colorectal Carcinomatosis:
                                                                                                                                                                  Source:
                                                                                                                                                                  Annals of Surgical Oncology. 2007, Lambert, Laura A. and Paul F. Mansfield. 
                                                                                                                                                                  See:
                                                                                                                                                                  http://www.annalssurgicaloncology.org/cgi/content/full/14/11/3037

                                                                                                                                                                  Laparoscopic Staging for Gastric Cancer
                                                                                                                                                                  Source: Dr Paul Mansfield, MDACC, Annals of Surgical Oncology, 2001


                                                                                                                                                                  Laparoscopy for Surgical Oncology
                                                                                                                                                                  Source: MDACC


                                                                                                                                                                  Articles by Dr Brendan J Moran, United Kingdom


                                                                                                                                                                  Prospective longitudinal study of quality of life following cytoreductive surgery and intraperitoneal chemotherapy for pseudomyxoma peritonei.
                                                                                                                                                                  Alves S, Mohamed F, Yadegarfar G, Youssef H, Moran BJ.

                                                                                                                                                                  Pseudomyxoma Peritonei Centre, Basingstoke and North Hampshire Hospital Foundation Trust, Aldermaston Road, Basingstoke, Hampshire RG24 9NA, UK.

                                                                                                                                                                  Abstract

                                                                                                                                                                  BACKGROUND: Pseudomyxoma peritonei (PMP) is characterized by mucinous ascites, predominantly arising form a perforated tumour of the appendix. This study aimed to assess Health-Related Quality of Life (HRQL) in patients following cytoreductive surgery and intraperitoneal chemotherapy for PMP.

                                                                                                                                                                  METHODS: Over a one year period, 49 consecutive patients (13 male, 36 females) with a median age of 55 (range 37-81 years) were enrolled. Patients were asked to complete the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire prior to surgery and at one, three, six and twelve months post-operatively.

                                                                                                                                                                  RESULTS: 26 patients (53%) underwent complete cytoreduction and 20 (42%) patients had major tumour debulking. One patient died from progressive disease three months from surgery and two patients withdrew from the study within 6 months of surgery. Baseline questionnaire compliance was 100 per cent and remained high (overall 98% of eligible patients) during follow up. Grade III/IV morbidity occurred in 4 patients (9%). Patients undergoing both complete cytoreduction and major tumour debulking reported a clinically significant improvement in emotional well-being, appetite and global HRQL at 1 year following surgery.

                                                                                                                                                                  CONCLUSION: Despite the high morbidity associated with cytoreductive surgery and intraperitoneal chemotherapy, an improvement in quality of life at 1 year following the procedure was seen following both complete cytoreduction and major tumour debulking. Longer term assessment is required to demonstrate the durability of this enhancement.

                                                                                                                                                                  RS and HIPEC for the Treatment of Patients age 30-77 years
                                                                                                                                                                  Source: North Hampshire Hospital, Basingstoke UK, 2007

                                                                                                                                                                  Articles by Prof David L Morris, Australia 

                                                                                                                                                                  Radiofrequency Ablation for Treatment of Unresectable Colorectal Pulmonary Metastes

                                                                                                                                                                  Radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases. Radiofrequency ablation for colorectal pulmonary metastases represents a step forward towards a nonsurgical option of combining systemic and local treatment for metastatic disease and is a safe treatment with a low risk profile.
                                                                                                                                                                  Source: David L. Morris, MD, PhD 2009

                                                                                                                                                                  Morbidity and Mortality: Study of HIPEC and CRS for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgery, Feb 2009, Dr David Morris, Dr Tristan Yan

                                                                                                                                                                  DPAM: Peritonectomy Improves Survival

                                                                                                                                                                  Source Prof David L Morris, 2009


                                                                                                                                                                  Assessment of risk factors following CRS and chemotherapy
                                                                                                                                                                  Source: Dr David L Morris, Dr Tristan Yan, 2009


                                                                                                                                                                  Cost effectiveness of treatment with CRS and HIPEC
                                                                                                                                                                  Source: Dr David L Morris, Dr Tristan Yan, Dec 2009

                                                                                                                                                                  Pseudomyxoma Peritonei Long Term Survival (10 year study) 
                                                                                                                                                                  Source: Annals of Surgical Oncology, 2009, Prof David L Morris, St George Hospital,Univ of New South Wales, Sydney, NSW, AU

                                                                                                                                                                  Long-term survival in patients with pseudomyxoma peritonei treated with cytoreductive surgery and perioperative intraperitoneal chemotherapy: 10 years of experience. 

                                                                                                                                                                  This report demonstrates long-term survival outcomes, acceptable perioperative outcomes, and a learning curve associated with the treatment of patients with pseudomyxoma peritonei.

                                                                                                                                                                  In vivo model for Pseudomyxoma Peritonei research
                                                                                                                                                                  Source: Prof David L Morris, Sydney Australia, 2009

                                                                                                                                                                  Articles by Dr Stefaan Mulier, Belgium

                                                                                                                                                                  Dr Stefaan Mulier provides HIPEC treatment for Pseudomyxoma Peritonei and Peritoneal Carcinomatosis 
                                                                                                                                                                  Source: Leopold Park Clinic in Brussels


                                                                                                                                                                  Articles by Dr Herwart Mueller, German

                                                                                                                                                                  CRS for Senior Patients
                                                                                                                                                                  Source: Dr Herwart Mueller, Germany

                                                                                                                                                                  Articles by Dr Garrett M Nash USA

                                                                                                                                                                  Laparoscopic Surgery for the Treatment of Peritoneal Surface Malignancies including Pseudomyxoma Peritonei
                                                                                                                                                                  Source: Memorial Sloan Kettering, NY

                                                                                                                                                                  Articles by Dr Michael B Nicholl, USA

                                                                                                                                                                  1. Nicholl M, Shilyansky J, Ota D. Management of malignant large bowel obstruction.
                                                                                                                                                                  Contemp Surg 2002; August: 396-400.


                                                                                                                                                                  2. Nicholl M, Pitt H, Wolf P, Cooney J, Kalayoglu M, Shilyansky J, Rikkers L. Choledochal
                                                                                                                                                                  cysts in Western adults: complexities compared to children. J Gastrointest Surg
                                                                                                                                                                  2004; 8:245-52.


                                                                                                                                                                  3. Nicholl M, Lodge A, Brown I, Sugg S, Shilyansky J. Restored immune response to an
                                                                                                                                                                  MHC-II restricted antigen in tumor-bearing hosts after elimination of regulatory T
                                                                                                                                                                  cells. J Pediatr Surg 2004; 39:941-6.


                                                                                                                                                                  4. Lodge A, Yu P, Nicholl M, Brown I, Jackson C, Schreiber K, Sugg S, Schreiber H,
                                                                                                                                                                  Shilyansky J. CD 40 ligation restores cytolytic response and eliminates fibrosarcoma
                                                                                                                                                                  in the peritoneum of mice lacking CD4+ T cells. Cancer Immunol Immunother 2006;
                                                                                                                                                                  55:1542-52.


                                                                                                                                                                  5. Nicholl MB, Bilchik AJ. Radiofrequency ablation of colorectal carcinoma liver
                                                                                                                                                                  metastases. Curr Colorectal Cancer Rep 2007; 3:99-103.


                                                                                                                                                                  6. Nicholl MB, Morton DL. Sentinel node biopsy in melanoma: standard of care. Am J
                                                                                                                                                                  Hematol Oncol 2007; 6:468-471.


                                                                                                                                                                  7. Nicholl M, Bilchik AJ. Is routine use of sentinel node biopsy justified in colon cancer?
                                                                                                                                                                  Ann Surg Oncol 2008; 15:1-3.


                                                                                                                                                                  8. Nicholl MB, Bilchik AJ. Thermal ablation of hepatic malignancy: useful but still not
                                                                                                                                                                  optimal. Eur J Surg Oncol 2008; 34:318-23.


                                                                                                                                                                  9. Huang SK, Darfler MM, Nicholl MB, You J, Bemis KG, Tegeler TJ, Wang M, Wery J,
                                                                                                                                                                  Chong KK, Nguyen L, Scolyer RA, Hoon DSB. LC/MS-based quantitative proteomic
                                                                                                                                                                  analysis of paraffin-embedded archival melanomas reveals potential proteomic
                                                                                                                                                                  biomarkers associated with metastasis. PLoS ONE 2009;4(2): e4430.


                                                                                                                                                                  10. Conway WC, Faries MB, Nicholl MB, Terando AM, Glass EC, Sim M, Morton DL. Age-
                                                                                                                                                                  related lymphatic dysfunction in malignant melanoma patients. Ann Surg Oncol.
                                                                                                                                                                  2009 Jun;16(6):1548-52.


                                                                                                                                                                  11. Nicholl MB, Wright B, Conway WC, Aarnes-Leong T, Sim M, Faries M. Does
                                                                                                                                                                  specialized surgical training increase lymph node yield in colon cancer? Am Surg
                                                                                                                                                                  2009 Oct; 75(10): 887-91.


                                                                                                                                                                  12. Nicholl MB, Conway WC, Ye X, Bilchik A, Singh G. Should Microwave Energy Be
                                                                                                                                                                  Preferred to Radiofrequency Energy for Malignant Liver Tumor Ablation? J
                                                                                                                                                                  Interventional Oncol 2010; 3(1): 12-16.


                                                                                                                                                                  13. Nicholl MB, Ahuja V, Conway WC, Vu VD, Sim M, Singh G. Small Bowel
                                                                                                                                                                  Adenocarcinoma: Understaged and Undertreated? Ann Surg Oncol 2010;
                                                                                                                                                                  17(10):2728-32.


                                                                                                                                                                  14. Nicholl MB, Takeuchi H, Elashoff D, Morton DL, Hoon DSB. Molecular upstaging of
                                                                                                                                                                  paraffin-embedded sentinel lymph nodes predicts long-term outcome in melanoma
                                                                                                                                                                  patients. Ann Surg 2011;253(1):116-22.


                                                                                                                                                                  15. Nguyen T, Kuo C, Nicholl MB, Sim M, Turner RR, Morton DL, Hoon DSB. Down-
                                                                                                                                                                  regulation of MicroRNA-29c is Associated with Hypermethylation of Tumor-Related
                                                                                                                                                                  Genes and Disease Outcome in Cutaneous Melanoma. Epigenetics. 2011 Mar 1;6(3).
                                                                                                                                                                  [Epub ahead of print]


                                                                                                                                                                  16. Fang J, Nicholl MB. Sirtulin 1 and malignant transformation: Friend or foe? Cancer
                                                                                                                                                                  Lett. 2011 Mar 15. [Epub ahead of print]


                                                                                                                                                                  17. Wheeler AA, Dale PS, Nicholl MB. Age influences likelihood of treatment, but not
                                                                                                                                                                  outcome, in pancreatic cancer. In preparation


                                                                                                                                                                  18. Macarthur K, Nicholl MB. Principles and innovations in peritoneal surface
                                                                                                                                                                  malignancy treatment. In preparation.


                                                                                                                                                                  Articles by Dr Haydee Ojeda-Fournier, USA   

                                                                                                                                                                  Diagnostic Imaging of Pancreatic Cancer
                                                                                                                                                                  Source: Dr Haydee Ojeda-Fournier, UCSD

                                                                                                                                                                  Articles by Dr Evan Ong, USA

                                                                                                                                                                  Greenstein SM, Delrio M, Ong E, Feuerstein D, Schechner R, Kim D, Corey H, Kaskel R, Tellis VA, Moritz ML. Plasmapheresis treatment for recurrent focal sclerosis in pediatric renal allografts. Pediatr Nephrol. 2000; 14 (12):1061-5.
                                                                                                                                                                    Babcock TA, Novak T, Ong E, Jho DH, Helton WS, Espat NJ. Modulation of LPS-stimulated macrophage TNF production by ω-3 fatty acid is associated with differential cyclooxygenase-2 (COX-2) enzyme translation and is independent of interleukin-10 (IL-10). Journal of Surgical Research 2002 Sep; 107 (1):135   Ong E, Helton WS, Espat NJ.Operative Experience of U.S. General Surgery Residents: Liver and Pancreas 1989-2001.Journal of Gastrointestinal Surgery. 2003 Feb;7(2):311   Ong E, Gao XP, Xu N, Predescu D, Rahman A, Broman MT, Jho DH, Malik AB. E. coli Pneumonia Induces CD-18 Independent Airway Neutrophil Transalveolar Migration In the Absence of Increased Lung Vascular Permeability. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2003 Oct;285(4):L879-88   Espat NJ, Ong E, Helton WS, Nyhus LM. 1990-2001 U.S. General Surgery Chief Resident Gastric Surgery operative Experience: Analysis of Paradigm Shift. Journal of Gastrointestinal Surgery. 2004 May-Jun;8(4):471-8   Ong E,Gao XP, Predescu D, Broman M, Malik AB. Phosphatidylinositol 3-Kinase Regulation of Neutrophil Extravasation: Role in Lung Inflammation. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2005 December; 289 (6): L1094-103.   Ong E, Jho D, Helton WS, Espat NJ. Surgisis®-assisted Delayed Repair of a Complex Bile Duct Injury after Laparoscopic Cholecystectomy. Journal of Gastrointestinal Surgery. 2006 February; 10(2): 202-6.   Sharif S, Broman M, Babcock T, Ong E, Jho D, Rudnicki M, Helton WS, Espat NJ. A Priori Dietary {Omega}-3 Lipid Supplementation Results in Local Pancreatic Macrophage and Pulmonary Inflammatory Response Attenuation in a Model of Experimental Acute Edematous Pancreatitis (AEP). Journal of Parenteral and Enteral Nutrition. 2006 July-August; 30(4): 271-6.   Jho DH, Jho DJ, Chejfec G, Ahn M, Ong E, Espat NJ. Primary biliary B-cell lymphoma of the cystic duct causing obstructive jaundice. The American Surgeon. 2007 May; 73(5): 508-10.   Ong EAlassas M, Bullard Dunn KM, Rajput A. Colorectal Cancer Surgery in the Elderly: Acceptable Morbidity? American Journal of Surgery. 2008 Mar; 195(3):344-8; discussion 348.   Brovkovych V, Gao XP, Ong E,Brovkovych S, Brennan ML, Su X, Hazen SL, Malik AB, Skidgel RA. Augmented iNOS Expression and Increased NO Production Reduce Sepsis-Induced Lung Injury and Mortality in Myeloperoxidase-Null Mice. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2008 Jul;295(1):L96-103.   Ong E, Alassas M, Bogner PN, Bullard Dunn KM, Chey WY, Gibbs J. Total Gastrectomy for Gastric Dysplasia in a patient with Attenuated Familial Adenomatous Polyposis Syndrome. The Journal of Clinical Oncology 2008 Jul 20;26(21):3641-2.
                                                                                                                                                                  Articles by Dr Gloria Ortega-Perez, Spain

                                                                                                                                                                  Patient Selection for CRS and HIPEC
                                                                                                                                                                  Source: Journal of Surgical Oncology 2009


                                                                                                                                                                  Articles by Dr James Pingpank, USA

                                                                                                                                                                  Peritoneal Carcinomatois Clinical Trials Study
                                                                                                                                                                  Source: NIH, Dr James Pingpank, Feb 2009


                                                                                                                                                                  Articles by Prof Pompiliu Piso, Germany

                                                                                                                                                                  Peritoneal Carcinomatosis Treatment (Study) with Tumor Honing Peptides
                                                                                                                                                                  Source: Dept of Radiology, Germany 2009

                                                                                                                                                                  Peritoneal Carcinomatosis Prognosis following treatment with surgery and HIPEC
                                                                                                                                                                  Source: Prof P Piso, 2009

                                                                                                                                                                  CRS and HIPEC for the Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Prof Pompiliu Piso, 3rd Annual Symposium, 2008

                                                                                                                                                                  HIPEC Study with laboratory rats
                                                                                                                                                                  Source: Deutscher Krebskongress, 2004

                                                                                                                                                                  Articles by Dr B Ronnett, USA

                                                                                                                                                                  CRS and HIPEC for the Treatment of Peritoneal Dissemination of Appendiceal and Colorectal Neoplasms
                                                                                                                                                                  Source: Dr Edward Levine, ASCO 2008

                                                                                                                                                                  DPAM Long Term Survival
                                                                                                                                                                  Source: Dr BM Ronnett, Dr Paul H Sugarbaker, 2009

                                                                                                                                                                  Articles by Dr Armando Sardi, USA

                                                                                                                                                                  CRS and HIPEC offer longterm survival for Peritoneal Carcinomatosis of disseminated Appendiceal tumor origin
                                                                                                                                                                  Source: Dr Armando Sardi, Mercy Med Center, Journal of American College of Surgeons, Sept 2009

                                                                                                                                                                  Published abstracts by Dr Armando Sardi
                                                                                                                                                                  Source: Mercy Medical Center


                                                                                                                                                                  Steps to Prepare for SurgerySource: Mercy Medical Center

                                                                                                                                                                  Curriculum Vitae for Dr Armando Sardi
                                                                                                                                                                  Source: Mercy Medical Center

                                                                                                                                                                  Profile for Dr Armando Sardi
                                                                                                                                                                  Source: Mercy Medical Center

                                                                                                                                                                  Complete cytoreduction offers longterm survival in patients with peritoneal carcinomatosis from appendiceal tumors of unfavorable histology.
                                                                                                                                                                  Source:J Am Coll Surg. 2009 Sep;209(3):308-12. Epub 2009 Jul 9.PMID: 19717034

                                                                                                                                                                  Pseudomyxoma peritonei: is disease progression related to microbial agents? A study of bacteria, MUC2 AND MUC5AC expression in disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis.
                                                                                                                                                                  Source: Ann Surg Oncol. 2008 May;15(5):1414-23. Epub 2008 Feb 26.PMID: 18299935

                                                                                                                                                                  Articles by Dr Perry Shen, USA

                                                                                                                                                                  Dr Perry Shen at WFU provides HIPEC
                                                                                                                                                                  Source: Wake Forest University

                                                                                                                                                                  Articles by Dr Paul H Sugarbaker, USA

                                                                                                                                                                  Surgical Responsibilities in the Management of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, June 2010, Pub Med

                                                                                                                                                                  Mesenteric Cyst resulting in Pseudomyxoma Peritonei
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, 2010

                                                                                                                                                                  Tailgut Cyst: An Unusual Case of Pseudomyxoma Peritonei
                                                                                                                                                                  Source: Tumori, Dr Paul H Sugarbaker, 2009

                                                                                                                                                                  Epithelial appendiceal neoplasms (abstract with availability to purchase article in full)
                                                                                                                                                                  Source: The Cancer Journal, 2009

                                                                                                                                                                  Epithelial appendiceal neoplasms: report reviews 900 cases treated at the Washington Hospital Center
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, Cancer Journal, May 2009

                                                                                                                                                                  DPAM Long Term Survival
                                                                                                                                                                  Source: Dr BM Ronnett, Dr Paul H Sugarbaker, 2009

                                                                                                                                                                  Management of mucinous urachal neoplasm presenting as Pseudomyxoma Peritonei
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, 2008

                                                                                                                                                                  Failure Analysis of Recurrent Disease Following CRS and IPC for Colorectal Cancer with Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, Dr Tristan Yan, 2007

                                                                                                                                                                  Treatment of Peritoneal Surface Malignancy
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, Dr Tristan Yan, Journal of Transistional Medicine, 2006

                                                                                                                                                                  Cytoreductive Surgery (includes graphic illustrations) Source: Dr Paul H Sugarbaker

                                                                                                                                                                  Indications for use of CRS and HIPEC
                                                                                                                                                                  Source: Dr Paul H Sugarbaker

                                                                                                                                                                  Appendix Cancer Prognosis
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, Washington Hospital Center

                                                                                                                                                                  Prognostic indicators for Peritoneal Carcinomatosis originating with gastrointestinal adenocarcinoma
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, 2005

                                                                                                                                                                  Atlas of Appendix Cancer(includes graphic illustrations)
                                                                                                                                                                  Source: Dr Paul H  Sugarbaker


                                                                                                                                                                  Articles referring to Dr Paul Sugarbaker and his patients
                                                                                                                                                                  Source: PMP Pals' Network

                                                                                                                                                                  Articles by Dr Jeffrey Sussman, USA

                                                                                                                                                                  VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon.Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA.Division of Surgical Oncology, Department of Surgery, University of Cincinnati Medical Center, 234 Goodman St., ML #0772, Cincinnati, Ohio 45219, USA.             Source:Ann Surg Oncol. 2008 Mar;15(3):738-44. Epub 2007 Nov 28.

                                                                                                                                                                  Articles by Dr Vicktor J Verwaal, Holland

                                                                                                                                                                  Population Based Study of Appendiceal Neoplasms and Pseudomyxoma Peritonei
                                                                                                                                                                  Source: ESJO, 2008


                                                                                                                                                                  Cytoreduction and HIPEC Treatment for Appendix Cancer and Pseudomyxoma Peritonei (pdf)
                                                                                                                                                                  Source: Netherlands Cancer Institute, Prof VJ Verwaal, 2006

                                                                                                                                                                  Articles by Dr Tristan Yan, Australia

                                                                                                                                                                  Cost effectiveness of treatment with CRS and HIPEC
                                                                                                                                                                  Source: Dr David L Morris, Dr Tristan Yan, Dec 2009

                                                                                                                                                                  Morbidity and Mortality: Study of HIPEC and CRS for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgery, Feb 2009, Dr David Morris, Dr Tristan Yan

                                                                                                                                                                  Assessment of risk factors following CRS and chemotherapy
                                                                                                                                                                  Source: Dr David L Morris, Dr Tristan Yan, 2009

                                                                                                                                                                  Failure Analysis of Recurrent Disease Following CRS and IPC for Colorectal Cancer with Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, Dr Tristan Yan, 2007

                                                                                                                                                                  Treatment of Peritoneal Surface Malignancy
                                                                                                                                                                  Source: Dr Paul H Sugarbaker, Dr Tristan Yan, Journal of Transistional Medicine, 2006

                                                                                                                                                                  Articles by Dr H Zeh, USA

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients
                                                                                                                                                                  Source: Journal of Clinical Oncology 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgical Oncology, 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Colorectal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgial Oncology, Nov 2008

                                                                                                                                                                  Articles by Dr F Zoetmulder, Holland

                                                                                                                                                                  Population Based Study of Appendiceal Neoplasms and Pseudomyxoma Peritonei
                                                                                                                                                                  Source: ESJO, 2008



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                                                                                                                                                                  [Treatment of pseudomyxoma peritonei is developing]

                                                                                                                                                                  Lepistö A, Osterlund P, Järvinen HJ.

                                                                                                                                                                  Duodecim. 2010;126(14):1693-9. Finnish. PMID: 20804088 [PubMed - in process]Related citations

                                                                                                                                                                  Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: a multi-institutional study of 1290 patients.

                                                                                                                                                                  Glehen O, Gilly FN, Boutitie F, Bereder JM, Quenet F, Sideris L, Mansvelt B, Lorimier G, Msika S, Elias D; the French Surgical Association.

                                                                                                                                                                  Cancer. 2010 Aug 24. [Epub ahead of print]PMID: 20737573 [PubMed - as supplied by publisher]Related citations

                                                                                                                                                                  Secondary Cytoreduction and Perioperative Intraperitoneal Chemotherapy after Initial Debulking of Pseudomyxoma Peritonei: A Study of Timing and the Impact of Malignant Dedifferentiation.

                                                                                                                                                                  Chua TC, Al-Zahrani A, Saxena A, Liauw W, Zhao J, Morris DL.

                                                                                                                                                                  J Am Coll Surg. 2010 Aug 20. [Epub ahead of print]PMID: 20729102 [PubMed - as supplied by publisher]Related citations

                                                                                                                                                                  [Prospective study of quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy using oxaliplatin for peritoneal carcinomatosis.]

                                                                                                                                                                  Lim C, Tordjmann D, Gornet JM, Nemeth J, Valleur P, Pocard M.

                                                                                                                                                                  Bull Cancer. 2010 Aug 6. [Epub ahead of print] French. PMID: 20693116 [PubMed - as supplied by publisher]Related citations

                                                                                                                                                                  Primary peritonectomy/HIPEC for disseminated peritoneal adenomucinosis achieves much lower recurrence rates and better survival than secondary procedures.

                                                                                                                                                                  Zhu KJ, Morris DL.

                                                                                                                                                                  Surgeon. 2009 Dec;7(6):345-50.PMID: 20681377 [PubMed - indexed for MEDLINE]Related citations

                                                                                                                                                                  Mucinous adenocarcinomas with intra-abdominal dissemination: a review of current therapy.

                                                                                                                                                                  Winder T, Lenz HJ.

                                                                                                                                                                  Oncologist. 2010;15(8):836-44. Epub 2010 Jul 23.PMID: 20656916 [PubMed - in process]Related citations

                                                                                                                                                                  [Prognostic factors and reproductive outcomes of borderline ovarian tumors: a review of 186 patients]

                                                                                                                                                                  Tao T, Cao DY, Yang JX, Huang HF, Wu M, Pan LY, Lang JH, Guo LN, Shen K.

                                                                                                                                                                  Zhonghua Yi Xue Za Zhi. 2010 May 18;90(19):1304-8. Chinese. PMID: 20646576 [PubMed - indexed for MEDLINE]Related citations

                                                                                                                                                                  Case records of the Massachusetts General Hospital. Case 19-2010. A 35-year-old man with adenocarcinoma of the cecum.

                                                                                                                                                                  Ryan DP, Engelman JA, Ferrone CR, Sahani DV, Lisovsky M.

                                                                                                                                                                  N Engl J Med. 2010 Jun 24;362(25):2411-9. No abstract available. PMID: 20573930 [PubMed - indexed for MEDLINE]Related citations

                                                                                                                                                                  Mesenteric cyst: report of a case-resulting in pseudomyxoma peritonei.

                                                                                                                                                                  Zappa L, Sugarbaker PH.

                                                                                                                                                                  Tumori. 2010 Mar-Apr;96(2):332-5.PMID: 20572595 [PubMed - indexed for MEDLINE]Related citations



                                                                                                                                                                  [Peritoneal carcinosis can have as good a prognosis as primary colonic cancer, and should be managed according to evidence-based practice]

                                                                                                                                                                  Graf W, Mahteme H.

                                                                                                                                                                  Lakartidningen. 2010 May 12-25;107(19-20):1320. Swedish. No abstract available. PMID: 20556987 [PubMed - indexed for MEDLINE]Related citations

                                                                                                                                                                   

                                                                                                                                                                   



                                                                                                                                                                  Copyright (c) 2012 PMP Pals' Network. All rights reserved. Website design by PMP Pals' Publishing. Information on this website is not intended as a substitute for licensed, professional medical advice. Each case is unique. Patients should seek the counsel of their own licensed, healthcare professional(s.)