Peritoneal Surface Malignancies
Resources, Referrals, Research, and Support for PSM
What is a Peritoneal Surface Malignancy?
Where can I find treatment for my peritoneal surface malignancy?
Why is HIPEC a treatment for peritoneal surface malignancies?
How can I talk with other PSM treatment patients?
Where can I find treatment for my peritoneal surface malignancy?
Why is HIPEC a treatment for peritoneal surface malignancies?
How can I talk with other PSM treatment patients?
Analysis of CRS and HIPEC for the Treatment of PSMs
Multidimensional Analysis of the Learning Curve for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Surface Malignancies
Kusamura, Shigeki MD, PhD; Baratti, Dario MD; Deraco, Marcello MD
Objective: To evaluate the learning curve of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in treating peritoneal surface malignancies (PSM).
Summary and Background: CRS and HIPEC to treat PSM is a complex procedure with a significant morbidity. A long-lasting training program is required to acquire expertise in this type of operation.
Methods: We performed CRS using peritonectomy procedures. HIPEC through the closed abdomen technique employed cisplatin and mitomycin-C or cisplatin and doxorubicin. Risk-adjusted sequential probability ratio test was used to assess the learning curve on a series of 420 cases of PSM on the basis of rates of incomplete cytoreduction and G3-5 morbidity (NCI-CTCAE v3). We determined control limits setting the type I/II error rates and unacceptable odds ratios (ORs) for the outcomes being studied. We performed the risk adjustment using logistic regression model.
Results: Rates of incomplete cytoreduction, G3-5 morbidity, and postoperative mortality rates were 10.2%, 28.5%, and 2.1%, respectively. The risk-adjusted sequential probability ratio test curve crossed the lower control limit at the 137th and 149th case, respectively, for incomplete cytoreduction and G3-5 morbidity. At those points, the actual ORs are lower than the prespecified ORs for outcomes being studied. Therefore, we estimated that approximately 140 cases are necessary to ensure surgical proficiency in CRS and HIPEC.
Conclusions: CRS and HIPEC to treat PSM has a steep learning curve requiring 140 procedures to acquire expertise.
Source: Annals of Surgery February 2012 - Volume 255 - Issue 2 - p 348–356
doi: 10.1097/SLA.0b013e3182436c28 © 2012 Lippincott Williams & Wilkins, Inc.
What is a Peritoneal Surface Malignancy?
Peritoneal Surface Malignancies (PSM) may include any of the following:
Malignant Mesothelioma
Carcinoma of the Appendix
Ovarian Sarcoma
Ovarian Stromal Cancer
Pseudomyxoma Peritonei
Colon Cancer
Ovarian Epithelial Cancer
Ovarian Germ Cell Tumor
Meet other PSM Patients and their Families!
Are you a patient or a family caregiver seeking treatment for a Peritoneal Surface Malignancy?
Join the PMP Pals' Network and communicate directly with other PSM patients
How are Peritoneal Surface Malignancies Treated?
What is the treatment for a Peritoneal Surface Malignancy?
Medical journal articles describing treatment for peritoneal surface malignancies
Source: ASCO
Treatment for Peritoneal Surface Malignancies generally includes specialized CRS cytoreductive surgery (peritonectomy) with HIPEC.
What is HIPEC?
HIPEC, or Hyperthermic intraperitoneal chemotherapy, provides specially trained surgeons with the ability to apply heated chemotherapy directly within and throughout the peritoneal cavity, for the purpose of killing any hidden tumor cells that may not have been removed during CRS (cytoreductive surgery.)
Regionally applied chemotherapy, or HIPEC, may increase the efficacy of cancer treatment, without causing significant toxicity to the remainder of the body.
HIPEC has become a standard course of care for many appendiceal, colorectal and ovarian cancer cases, as well as for the treatment of Pseudomyxoma Peritonei and other Peritoneal Surface Malignancies (PSMs.)
Learn more about HIPEC
Where Can I Find a Treatment Specialist for my Peritoneal Surface Malignancy?
The following is an international listing, in alphabetical order, of surgical oncologists and HIPEC treatment centers who have demonstrated experience in treating Appendix Cancer, Colorectal Cancers, Pseudomyxoma Peritonei, and peritoneal surface malignancies.
The PMP Pals’ Network does not endorse any particular surgeon, specialist or cancer treatment center. We simply share practical information with the intention of saving precious time in seeking medical.
Read additional "profiles" of these specialists in: the PMP Pals’ Network Newsletter
and in the PMP Pals’ Network Handbooks:"Physician Consultations" and "Preparing for Surgery."
As a volunteer patient advocacy program, representing the needs of patients and their families, we neither solicit, nor receive funding or advertising revenue from cancer treatment centers, pharmaceutical companies, or physicians who treat cancer or provide HIPEC.
Each patient's case is unique and should be evaluated on an individual basis.
Surgeon Specialists in the Treatment of Peritoneal Surface Malignancies
Dr Syed Ahmad, Surgical Oncologist, UC Barrett, Cincinnati OH, USA
Dr Steven A Ahrendt, Surgeon, UPMC Hillman Cancer Center, Pgh, PA, USA
ASPSM
Dr Steven A Ahrendt is a member of the ASPSM
Dr Richard H Alexander, University of Maryland, USA
Read the profile for Dr Richard H Alexander and contact him directly for a consultation
Ph: Surgical Oncology Service at 410-328-7320
or Angela at 410-328-8382
or LaToya at 410-328-7798.
ASPSM
Dr H Richard Alexander is a member of the ASPSM
Dr H Richard Alexander provides HIPEC Treatment at the Greenbaum Cancer Center
Dr Mazin Al-Kasspooles, Surgical Oncologist, Kansas City, KS
Read the profile for Dr Mazin F Al-Kasspooles and schedule a consultation
Mazin Al-kasspooles, MD, FACS, Associate Professor of Surgery, Surgical Oncology
University of Kansas Medical Center
3901 Rainbow Boulevard, Mail Stop 2005,Kansas City, Kansas 66160
Contact via PH: 913-588-6568 or Email: mal-kasspooles@kumc.edu
Mazin Al-kasspooles, MD, FACS, Associate Professor of Surgery, Surgical Oncology
University of Kansas Medical Center
3901 Rainbow Boulevard, Mail Stop 2005,Kansas City, Kansas 66160
Contact via PH: 913-588-6568 or Email: mal-kasspooles@kumc.edu
Dr David L Bartlett, Surgeon, UPMC Hillman Cancer Center, Pgh, PA, USA
Read the profile for Dr David L Bartlett and contact him for a consultation
David L Bartlett MD
Hilllman Cancer Center (UPMC), Pgh PA
David C. Koch Regional Perfusion
5150 Center Avenue Pittsburgh, PA 15232
Phone: (412) 692-2852
Assistant to Dr David L Bartlett Heather Jones, PA
Office Manager: Margaret J Corson
Peritoneal Surface Malignancy Specialty Care Centers, UPMC Hillman Cancer Center
David L Bartlett MD
Hilllman Cancer Center (UPMC), Pgh PA
David C. Koch Regional Perfusion
5150 Center Avenue Pittsburgh, PA 15232
Phone: (412) 692-2852
Assistant to Dr David L Bartlett Heather Jones, PA
Office Manager: Margaret J Corson
Peritoneal Surface Malignancy Specialty Care Centers, UPMC Hillman Cancer Center
ASPSM
Dr David L Bartlett is a member of the ASPSM
Dr Jean-Marc Bereder, Surgeon, Tulon, France
Dr Wim P Ceelen, Surgeon, Ghent University, Belgium
Prof dr Wim P Ceelen, MD, PhD, FACS Dienst Gastro-intestinale Heelkunde
Universitair Ziekenhuis Gent Department of Gastrointestinal Surgery
Ghent University Hospital De Pintelaan 185, B-9000 Gent, Belgium
Tel +32 9 332 62 51 Fax +32 9 332 38 91
wim.ceelen@ugent.be
www.surgery.ugent.be
www.uzgent.be
Universitair Ziekenhuis Gent Department of Gastrointestinal Surgery
Ghent University Hospital De Pintelaan 185, B-9000 Gent, Belgium
Tel +32 9 332 62 51 Fax +32 9 332 38 91
wim.ceelen@ugent.be
www.surgery.ugent.be
www.uzgent.be
Dr Marcello Deraco, Surgical Oncologist, Milan, Italy
Read the profile for Dr Marcello Deraco and contact him directly for a consultation
Dept of Surgery, Melanoma and Sarcoma Unit,
National Cancer Institute of Milan
Via Venezian, 1 - 20133 Milan Italy
Telephone/ Fax +39 02 76008435, +39 335-247236 ( Mobile )
E-mail marcelloderaco@hotmail.com Web www.marcelloderaco.com
ASPSM
Dr Marcello Deraco is a member of the ASPSM
Dr Dominque Elias, Surgeon Institut Gustave Roussy, France
Chairman of the Digestive and Hepato-Biliary Unit,
Chief of the Department of Surgical Oncology Department of Surgical Oncology,
Institut Gustave Roussy, Comprehensive Cancer Center.
Dr Jesus Esquivel, Surgeon, St Agnes Hospital, USA
Jesus Esquivel, MD, FACS, Director
Peritoneal Surface Malignancy Program
St. Agnes Hospital 900 Caton Ave Mail Box 207
Baltimore, Maryland 21229
Phone: 410-368-2743 Fax: 410-951-4007
email: jesquive@stagnes.org web: www.hipec.org
Assistant to Dr Esquivel, Robin Cianos RN
Peritoneal Surface Malignancy Program
St. Agnes Hospital 900 Caton Ave Mail Box 207
Baltimore, Maryland 21229
Phone: 410-368-2743 Fax: 410-951-4007
email: jesquive@stagnes.org web: www.hipec.org
Assistant to Dr Esquivel, Robin Cianos RN
ASPSM
Dr Jesus Esquivel is a member of the ASPSM
Dr Jan Franko, Surgeon, Mercy Medical Center, USA
ASPSM
Dr Jan Franko is a member of the ASPSM
Dr Francois N Gilly, Surgeon, Lyon, France
Centre Hospital-Universitaire Lyon Sud,
69495, Pierre Bénite Cedex, France.
Tel +33 478 861375
Dr Charles Goldman, Surgeon, Mercy Medical Center, USA
Dr Martin Goodman, Surgeon, Tufts University, USA
Dr Martin Goodman
Photo of Dr Martin Goodman, Copyright © PMP Pals’ Network
ASPSM
Dr Martin Goodman is a member of the ASPSM
Prof. Dr Joachim Jaehne, Klinik fur Allgemein, Germany
Prof. Dr. Joachim Jaehne,
DKH Oncologic Surgery, Hannover, GermanyKlinik für Allgemein- und Viszeralchirurgie
Schwerpunkt für endokrine und onkologische Chirurgie
Diakoniekrankenhaus Henriettenstiftung gGmbH
Marienstr. 72-90 D-30171 Hannover
Tel.: +495112892101 Fax: +495112892022
e-mail: joachim.jaehne@ddh-gruppe.de
www.diakoniekrankenhaus-henriettenstiftung.de
DKH Oncologic Surgery, Hannover, GermanyKlinik für Allgemein- und Viszeralchirurgie
Schwerpunkt für endokrine und onkologische Chirurgie
Diakoniekrankenhaus Henriettenstiftung gGmbH
Marienstr. 72-90 D-30171 Hannover
Tel.: +495112892101 Fax: +495112892022
e-mail: joachim.jaehne@ddh-gruppe.de
www.diakoniekrankenhaus-henriettenstiftung.de
Dr Matthew P Holtzman, UPMC Hillman Cancer Center, Pgh, PA, USA
ASPSM
Dr Matthew P Holtzman is a member of the ASPSM
Dr John Kane III, Surgeon, Roswell Park, USA
Dr Laura Lambert, Surgeon, UMass, USA
Learn more about the Peritoneal Surface Malignancy Program at UMass
Read profile for Dr Laura Lambert and contact her directly
ASPSM
Dr Laura Lambert is a member of the ASPSM
Dr Edward A Levine, Surgeon, Wake Forest University, USA
ASPSM
Dr Edward A Levine is a member of the ASPSM
Wake Forest University Comprehensive Cancer Treatment Center
Dr Steven Libutti, Surgeon, Montefiore-Einstein, USA
Dr Brian W Loggie, Surgical Oncologist, Creighton University, Omaha, KS, USA
Read the profile for Dr Brian W Loggie and contact him directly
Brian W. Loggie, MD, CM, FRCSC, FACS
Harold J. Bonnstetter Professor of Surgery
Chief, Division of Surgical Oncology
Creighton University Medical Center
601 N. 30th St, Omaha, NE 68131
Ph: (402) 280-5009 Fax: (402) 280-3448
Assistant to Dr Loggie: Holly Sennett APRN-BC
Ph 402-280-4100
Brian W. Loggie, MD, CM, FRCSC, FACS
Harold J. Bonnstetter Professor of Surgery
Chief, Division of Surgical Oncology
Creighton University Medical Center
601 N. 30th St, Omaha, NE 68131
Ph: (402) 280-5009 Fax: (402) 280-3448
Assistant to Dr Loggie: Holly Sennett APRN-BC
Ph 402-280-4100
Creighton University HIPEC Treatment Center, Omaha NE
Dr Andrew M Lowy, Surgeon, UCSD Thornton Hospital, San Diego, CA USA
Read the profile for Dr Andrew M Lowy and contact him directly
Assistant to Dr Andrew M. Lowy, Debbie Soldano RN
Dr Andrew M Lowy
Photo of Dr Andrew M Lowy, Copyright © PMP Pals’ Network
ASPSM
Dr Andrew M Lowy is a member of the ASPSM
UCSD Moores Cancer Center
Dr Haile Mahteme, Surgeon, Sweden
Dr Paul Mansfield, Surgical Oncologist, MD Anderson, Houston, TX, USA
Dr Juan Torres Melero, Surgical Oncologist, Hospital Torrecardenas, Spain
Dr. Juan Torres Melero
Head of the Peritoneal Surface Malignancy Program
Department of Surgery
Hospital Torrecárdenas, Almería. Spain 04009
E-mail: juantorresmelero@gmail.com
Phone: 34-950 016602 Fax: 34 950 016150
ASPSM
Dr Torres Melero is a member of the ASPSM
Hospital Torrecardenas, Almeria, Spain
Mr Brendan Moran, Pelican Cancer Centre, Basingstoke, United Kingdom
Dr Santiago Gonzalez Moreno, Surgeon, Spain
Centro Oncológico MD Anderson International España,
Calle Gómez Hemans 4,
28033 Madrid, Spain
Professor David L Morris, Surgical Oncologist, Australia
Professor David L Morris
UNSW Department of Surgery
St George Hospital Kogarah NSW 2217 Australia
Ph 61 2 9113 2070
Fax 61 2 9113 3997
Email david.morris@unsw.edu.au
UNSW Department of Surgery
St George Hospital Kogarah NSW 2217 Australia
Ph 61 2 9113 2070
Fax 61 2 9113 3997
Email david.morris@unsw.edu.au
ASPSM
Dr David L Morris is a member of the ASPSM
Dr Stefaan Mulier, Surgical Oncologist, Belgium
Dr Garrett M Nash, Surgical Oncologist, MSKCC, NYC, NY, USA
ASPSM
Dr Garrett M Nash is a member of the ASPSM
Dr Evan S Ong, Surgical Oncologist, University of Arizona
ASPSM
Dr Evan S Ong is a member of the ASPSM
Dr James F Pingpank, Surgeon, UPMC, Hillman Cancer Center, Pgh, PA, USA
Dr Pompiliu Piso, Surgical Oncologist, Regensburg, Germany
Prof. Dr. Pompiliu Piso
Krankenhaus Barmherzige Brüder Regensburg
Prüfeninger Straße 86
93049 Regensburg Germany
Tel: +49 941 369-2201
Email:Pompiliu.Piso@barmherzige-regensburg.de
Krankenhaus Barmherzige Brüder Regensburg
Prüfeninger Straße 86
93049 Regensburg Germany
Tel: +49 941 369-2201
Email:Pompiliu.Piso@barmherzige-regensburg.de
ASPSM
Prof Pompiliu Piso is a member of the ASPSM
Dr Alberto Gomez Portillo, Surgical Oncologist, Spain
ASPSM
Dr Gomez Portillo is a member of the ASPSM
Dr David C Rice, Surgeon, MDACC, Houston TX, USA
Dr Armando Sardi, Surgical Oncologist, Mercy Medical Center
Dr Perry Shen, Surgical Oncologist, Wake Forest University, USA
ASPSM
Dr Perry Shen is a member of the ASPSM
Wake Forest University Comprehensive Cancer Treatment Center
Dr John H Stewart IV, Surgical Oncologist, Wake Forest University, USA
ASPSM
Dr John H Stewart IV is a member of the ASPSM
Wake Forest University Comprehensive Cancer Treatment Center, Dr John H Stewart IV
WFU HIPEC Treatment Team
Dr Paul H Sugarbaker, Washington Hospital Center, Washington DC, USA
ASPSM
Dr Paul H Sugarbaker is a member of the ASPSM
Washington Hospital Center, Dr Paul H Sugarbaker
Dr Jeffrey Sussman, Surgical Oncologist, UC, Cinn, OH
ASPSM
Dr Jeffrey Sussman is a member of the ASPSM
Dr Walley Temple, Surgeon, Canada
Dr Atonios-Apostolos K Tentes, Surgeon,Didimotichon, Greece
Dr Atonios-Apostolos K Tentes
Didimotichon General Hospital
Didimotichon, 68300, Greece
Email atentes@did-hosp.gr
Dr V J Verwaal, Surgical Oncologist, Holland
Read the profile for Dr V J Verwaal and contact him directly
Vic J Verwaal MD PhD Surgeon
Head of the Peritoneal Surface Malignancy Unit
Coordinator of the GI surgery oncology group
Medical coordinator of the abdominal surgery ward
Chair of the EUPSOG
Colorectal and liver surgeon
The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
Phone: +31 20 512 2977
Email: v.verwaal@nki.nl
Mail: Plesmanlaan 121
1066 CX Amsterdam
Dr Herbert J Zeh, Surgeon, UPMC Hillman Cancer Center, Pgh, PA, USA
UPMC David C Koch Regional Perfusion Cancer Therapy Center, Pgh PA, Dr Herbert J Zeh
Hillman Cancer Center, Pgh PA
American Society of Peritoneal Treatment Malignancies
HIPEC Treatment Centers for Peritoneal Surface Malignancies
Centro Oncologico MD Anderson Internacional, Madrid, Espana
Greenbaum Cancer Center, Maryland, USA
UC San Diego Moores Cancer Center, San Diego, CA
St Agnes Hospital, Baltimore, MD
MD Anderson Cancer Treatment Center, Houston TX
Multidimensional Analysis of Learning Curve for CRS and HIPEC in PSMs
Photo courtesy Marcello Deraco
Multidimensional Analysis of Learning Curve for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Surface Malignancies
Kusamura, Shigeki MD, PhD; Baratti, Dario MD; Deraco, Marcello MD
Abstract
Objective: To evaluate the learning curve of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in treating peritoneal surface malignancies (PSM).
Summary and Background: CRS and HIPEC to treat PSM is a complex procedure with a significant morbidity. A long-lasting training program is required to acquire expertise in this type of operation.
Methods: We performed CRS using peritonectomy procedures. HIPEC through the closed abdomen technique employed cisplatin and mitomycin-C or cisplatin and doxorubicin. Risk-adjusted sequential probability ratio test was used to assess the learning curve on a series of 420 cases of PSM on the basis of rates of incomplete cytoreduction and G3-5 morbidity (NCI-CTCAE v3). We determined control limits setting the type I/II error rates and unacceptable odds ratios (ORs) for the outcomes being studied. We performed the risk adjustment using logistic regression model.
Results: Rates of incomplete cytoreduction, G3-5 morbidity, and postoperative mortality rates were 10.2%, 28.5%, and 2.1%, respectively. The risk-adjusted sequential probability ratio test curve crossed the lower control limit at the 137th and 149th case, respectively, for incomplete cytoreduction and G3-5 morbidity. At those points, the actual ORs are lower than the prespecified ORs for outcomes being studied. Therefore, we estimated that approximately 140 cases are necessary to ensure surgical proficiency in CRS and HIPEC.
Conclusions: CRS and HIPEC to treat PSM has a steep learning curve requiring 140 procedures to acquire expertise.
Annals of Surgery:
POST AUTHOR CORRECTIONS, 26 December 2011
doi: 10.1097/SLA.0b013e3182436c28
Original Article: PDF Only (C) 2011 Lippincott Williams & Wilkins, Inc.
Peritoneal Surface Malignancy Patients
ASPSM Patient Survey
The American Society of Peritoneal Surface Malignancies (ASPSM) was created to improve the care of patients afflicted with peritoneal malignancies. The ASPSM membership is comprised of more than 130 healthcare professionals from around the world. Pseudomyxoma Peritonei is among the diagnoses described as Peritoneal Surface Malignancies or PSMs.
Dr Jesus Esquivel and his colleagues of the ASPSM have developed a survey form for the collection of data regarding the diagnosis, treatment and outcome of treatment, for PSM patients. The ASPSM refers to this form as the “PROGRESS in Patient Initiated Program” form. The goal of the collection and analysis of the data is to help healthcare providers and patients understand the importance of
- early recognition of the common signs and symptoms of PSMs and the
- early referral to an appropriate treatment center.
The ASPSM PROGRESS form includes three pages, as follows:
Page 1: to be completed by the patient,
Page 2: to be signed by the patient and completed by the surgeon,
Page 3: the confidentiality statement to be checked and signed by the patient
Finally, the patient will fax or email the completed form back to the ASPSM for data collection.
Currently, the PROGRESS survey is limited to PSM patients residing and being treated in the USA.
Click here to download the PROGRESS survey form from the ASPSM website.
Dr Jesus Esquivel and his colleagues of the ASPSM have developed a survey form for the collection of data regarding the diagnosis, treatment and outcome of treatment, for PSM patients. The ASPSM refers to this form as the “PROGRESS in Patient Initiated Program” form. The goal of the collection and analysis of the data is to help healthcare providers and patients understand the importance of
- early recognition of the common signs and symptoms of PSMs and the
- early referral to an appropriate treatment center.
The ASPSM PROGRESS form includes three pages, as follows:
Page 1: to be completed by the patient,
Page 2: to be signed by the patient and completed by the surgeon,
Page 3: the confidentiality statement to be checked and signed by the patient
Finally, the patient will fax or email the completed form back to the ASPSM for data collection.
Currently, the PROGRESS survey is limited to PSM patients residing and being treated in the USA.
Click here to download the PROGRESS survey form from the ASPSM website.
8th International Conference on Peritoneal Surface Malignancies
Prof Pompiliu Piso, Dr Paul H Sugarbaker, and their colleagues in the Peritoneal Surface Oncology Group International, will welcome 450 of their peers to the 8th International Conference on Peritoneal Surface Malignancy.
The conference will convene in Berlin, October 31- November 1, 2012.
Conference topics will include:
Surgical treatment of peritoneal carcinomatosis, pseudomyxoma peritonei, gastric cancer, colorectal cancer, mesothelioma, ovarian cancer, and more.
Other topics of discussion will include:
perioperative and systemic chemotherapy, pathology and quality of life, post treatment.
The conference will convene in Berlin, October 31- November 1, 2012.
Conference topics will include:
Surgical treatment of peritoneal carcinomatosis, pseudomyxoma peritonei, gastric cancer, colorectal cancer, mesothelioma, ovarian cancer, and more.
Other topics of discussion will include:
perioperative and systemic chemotherapy, pathology and quality of life, post treatment.
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