Colorectal Cancer
Colon Cancer, Bowel Cancer
Lynch Syndrome: Inherited Cancer
Lynch Syndrome is the most common form of inherited colorectal cancer; summary of a public health meeting: Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.
Source:
Bellcross CA, Bedrosian SR, Daniels E, Duquette D, Hampel H, Jasperson K, Joseph DA, Kaye C, Lubin I, Meyer LJ, Reyes M, Scheuner MT, Schully SD, Senter L, Stewart SL, St Pierre J, Westman J, Wise P, Yang VW, Khoury MJ.
Source
1] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA [2] Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
January 2012
Abstract:
"Lynch syndrome is the most common cause of inherited colorectal cancer, accounting for approximately 3% of all colorectal cancer cases in the United States."
In 2009, an evidence-based review process conducted by the independent Evaluation of Genomic Applications in Practice and Prevention Working Group resulted in a recommendation to offer genetic testing for Lynch syndrome to all individuals with newly diagnosed colorectal cancer, with the intent of reducing morbidity and mortality in family members.
To explore issues surrounding implementation of this recommendation, the Centers for Disease Control and Prevention convened a multidisciplinary working group meeting in September 2010.
This article reviews background information regarding screening for Lynch syndrome and summarizes existing clinical paradigms, potential implementation strategies, and conclusions which emerged from the meeting. It was recognized that widespread implementation will present substantial challenges, and additional data from pilot studies will be needed. However, evidence of feasibility and population health benefits and the advantages of considering a public health approach were acknowledged.
Lynch syndrome can potentially serve as a model to facilitate the development and implementation of population-level programs for evidence-based genomic medicine applications involving follow-up testing of at-risk relatives. Such endeavors will require multilevel and multidisciplinary approaches building on collaborative public health and clinical partnerships.Genet Med 2012:14(1):152-162.
Source:
Bellcross CA, Bedrosian SR, Daniels E, Duquette D, Hampel H, Jasperson K, Joseph DA, Kaye C, Lubin I, Meyer LJ, Reyes M, Scheuner MT, Schully SD, Senter L, Stewart SL, St Pierre J, Westman J, Wise P, Yang VW, Khoury MJ.
Source
1] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA [2] Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
January 2012
Abstract:
"Lynch syndrome is the most common cause of inherited colorectal cancer, accounting for approximately 3% of all colorectal cancer cases in the United States."
In 2009, an evidence-based review process conducted by the independent Evaluation of Genomic Applications in Practice and Prevention Working Group resulted in a recommendation to offer genetic testing for Lynch syndrome to all individuals with newly diagnosed colorectal cancer, with the intent of reducing morbidity and mortality in family members.
To explore issues surrounding implementation of this recommendation, the Centers for Disease Control and Prevention convened a multidisciplinary working group meeting in September 2010.
This article reviews background information regarding screening for Lynch syndrome and summarizes existing clinical paradigms, potential implementation strategies, and conclusions which emerged from the meeting. It was recognized that widespread implementation will present substantial challenges, and additional data from pilot studies will be needed. However, evidence of feasibility and population health benefits and the advantages of considering a public health approach were acknowledged.
Lynch syndrome can potentially serve as a model to facilitate the development and implementation of population-level programs for evidence-based genomic medicine applications involving follow-up testing of at-risk relatives. Such endeavors will require multilevel and multidisciplinary approaches building on collaborative public health and clinical partnerships.Genet Med 2012:14(1):152-162.
Colorectal Cancer Screening Report
Colorectal Cancer Screening Report: Incidence, and Mortality in the United States, 2002--2010
Source: Centers for Disease Control 07.05.11
Source: Centers for Disease Control 07.05.11
American Society of Colon and Rectal Surgeons
American Society of Colon & Rectal Surgeons (ASCRS)
www.fascrs.org
www.fascrs.org
Colorectal Cancer Treatment Specialists
Is HIPEC Effective for the Treatment of Colorectal Cancer?
Cytoreductive Surgery and Hyperthermic Intraperitonal Chemotherapy: History Repeating Itself or a New Standard?
By David P. Ryan, MD
Harvard Medical School, Boston, MA and Massachusetts General Hospital Cancer Center, Boston, MA.
Source: © 2011 by American Society of Clinical Oncology. 1092-9118/10/1-10
By David P. Ryan, MD
Harvard Medical School, Boston, MA and Massachusetts General Hospital Cancer Center, Boston, MA.
Source: © 2011 by American Society of Clinical Oncology. 1092-9118/10/1-10
HIPEC is Effective for the Treatment of Colorectal Cancer?
Systematic Review on the Efficacy of Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis From Colorectal Carcinoma
by Tristan D. Yan, Deborah Black, Renaldo Savady, Paul H. Sugarbaker
Sources: Peritoneal Surface Malignancy Program, Washington Cancer Institute, Washington, DC; and the School of Public Health and Community Medicine, The University of New South Wales, Sydney, Australia.Address reprint requests to Paul H. Sugarbaker, MD, 106 Irving St, NW, Suite 3900N, Washington, DC, 20010; e-mail: Paul.Sugarbaker@medstar.net
by Tristan D. Yan, Deborah Black, Renaldo Savady, Paul H. Sugarbaker
Sources: Peritoneal Surface Malignancy Program, Washington Cancer Institute, Washington, DC; and the School of Public Health and Community Medicine, The University of New South Wales, Sydney, Australia.Address reprint requests to Paul H. Sugarbaker, MD, 106 Irving St, NW, Suite 3900N, Washington, DC, 20010; e-mail: Paul.Sugarbaker@medstar.net
Colorectal Cancer Treatment Highlights
Highlights from ASCO 2011
Source: Fight Colorectal Cancer
Source: Fight Colorectal Cancer
Exercise to Prevent Colon Cancer!
What is Colon Cancer?
Colon Polyps
"I Have Colon Polyps, Now What?" video presented by MD Anderson
Definition of Colon Cancer from NCI
"Cancer that forms in the tissues of the colon (the longest part of the large intestine). Most colon cancers are adenocarcinomas (cancers that begin in cells that make and release mucus and other fluids).Estimated new cases and deaths from colon and rectal cancer in the United States in 2011:
New cases: 101,340 (colon); 39,870 (rectal)
Deaths: 49,380 (colon and rectal combined)"
"Cancer that forms in the tissues of the colon (the longest part of the large intestine). Most colon cancers are adenocarcinomas (cancers that begin in cells that make and release mucus and other fluids).Estimated new cases and deaths from colon and rectal cancer in the United States in 2011:
New cases: 101,340 (colon); 39,870 (rectal)
Deaths: 49,380 (colon and rectal combined)"
Colorectal Cancer Awareness
Colorectal Cancer Facts
Colon Cancer Screening
Overview of Colon Cancer Screening at MD Anderson
Colorectal Cancer Screening
Colorectal Cancer and Chemotherapy
Colorectal Cancer Screening Options
Source: NYU
Colorectal Cancer Prevention
Colorectal Cancer Exercise and Dietary Guidelines Film
Source: NYU
Colon Cancer and Gene Variations
Gene Variations and Bowel Cancer Survival
Source: NCRI, Cardiff Wales, 2010
Source: NCRI, Cardiff Wales, 2010
Colorectal Cancer Risk Factors
Colorectal Cancer Fact Sheet: Causes and Risks for Colorectal Cancer
Source: National Cancer Institute
Colon Cancer Causes and Risks
Source: Pub Med
Colorectal Cancer Risk Factors
Source: CDC
Colon Cancer Screening
Cancer Care Conferences
Chemotherapy for Colorectal Cancers
Hereditary or Familial Cancers
Hereditary Cancers including gastric and colon cancers
Source: Creighton University
Hereditary Cancer Genes
Source: Creighton University
Hereditary Cancers including colorectal cancers
Source: MD Anderson
Nutrition for Colon Cancer Patients
Ostomy Care for Colon Cancer Patients
Ken leads an active life with an ostomy!
Resources for Colon Cancer Patients and Their Families
Seniors with Colorectal Cancer
Senior Colon Cancer Patients Require Specialized Post Op Care
Importance of the First Postoperative Year in the Prognosis of Elderly Colorectal Cancer Patients
Source: Annals of Surgery, March 2011
Recommended Reading
Colon and Rectal Cancer: A Comprehensive Guide for Patients and Families
Author: Lorraine Johnston
This book is a helpful addition to the library of any colorectal or gastrointestinal cancer patient.
Among the practical topics addressed are:
Managing your Finances, Insurance, and Employment During Medical Treatment
Tips for Communicating with Medical Personnel
Sexuality and Intimacy
Stress and the Immune System
Traveling Long Distance for Medical Care
Staging System Equivalents and, much more!
Educate yourself, and your loved ones with this informative book!
Author: Lorraine Johnston
This book is a helpful addition to the library of any colorectal or gastrointestinal cancer patient.
Among the practical topics addressed are:
Managing your Finances, Insurance, and Employment During Medical Treatment
Tips for Communicating with Medical Personnel
Sexuality and Intimacy
Stress and the Immune System
Traveling Long Distance for Medical Care
Staging System Equivalents and, much more!
Educate yourself, and your loved ones with this informative book!
Colorectal cancer surgery in the elderly: acceptable morbidity?
Ong ES, Alassas M, Dunn KB, Rajput A.
Abstract
BACKGROUND: Because of the increase in the geriatric population, an increasing number of elderly patients are being treated for colorectal cancer. The purpose of this study was to evaluate perioperative morbidity and mortality in this population.
METHODS: A retrospective chart review was performed for patients 80 years of age or older who underwent surgery for colorectal cancer (1993-2006).
RESULTS: Ninety patients were identified, with a median age of 84 years. More than 90% presented with symptoms; the remaining were diagnosed by screening colonoscopy. Emergent surgery was required in 10%. The morbidity rate was 21% and the overall 30-day mortality rate was 1.1%. Morbidity was higher in patients who required surgery emergently.
CONCLUSIONS: Despite advanced age, the majority of patients in this study did well. Postoperative morbidity was higher than in the general population, but we believe it was acceptably low in most patients. Colorectal surgery appears to be safe in most elderly patients.
Am J Surg. 2008 Mar;195(3):344-8
BACKGROUND: Because of the increase in the geriatric population, an increasing number of elderly patients are being treated for colorectal cancer. The purpose of this study was to evaluate perioperative morbidity and mortality in this population.
METHODS: A retrospective chart review was performed for patients 80 years of age or older who underwent surgery for colorectal cancer (1993-2006).
RESULTS: Ninety patients were identified, with a median age of 84 years. More than 90% presented with symptoms; the remaining were diagnosed by screening colonoscopy. Emergent surgery was required in 10%. The morbidity rate was 21% and the overall 30-day mortality rate was 1.1%. Morbidity was higher in patients who required surgery emergently.
CONCLUSIONS: Despite advanced age, the majority of patients in this study did well. Postoperative morbidity was higher than in the general population, but we believe it was acceptably low in most patients. Colorectal surgery appears to be safe in most elderly patients.
Am J Surg. 2008 Mar;195(3):344-8
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