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                                                                                                                                                                  HIPEC Treatment for Appendix Cancer

                                                                                                                                                                  Picture
                                                                                                                                                                  HIPEC is a common therapy for appendix cancer!


                                                                                                                                                                  HIPEC has become a common treatment therapy for the treatment of Appendix Cancer.







                                                                                                                                                                  What is HIPEC?

                                                                                                                                                                  Hyperthermic intraperitoneal chemotherapy, or HIPEC, is a procedure in which heated chemotherapy is circulated within the abdomen. The chemotherapy(ies) (most commonly Mitomycin C or Mitomycin C plus Oxaliplatin) are heated to 42°C or 107.6°F with the goal of killing any hidden tumor cells. HIPEC includes the use of a heated sterile solution with chemotherapy continuously circulated throughout the abdominal cavity for approximately 90 minutes.

                                                                                                                                                                  HIPEC treatment provides surgeons with the ability to apply high doses of chemotherapy directly into the peritoneal cavity without significant toxicity to the remainder of the body. The effects of heat with regionally applied chemotherapy, may increase the efficacy of the treatment, with the goal of achieving a cure. The HIPEC treatment is applied directly following peritonectomy or CRS (cytoreductive surgery.)

                                                                                                                                                                  HIPEC is also referred to as perfusion. HIPEC involves perfusion of the peritoneal cavity.

                                                                                                                                                                  HIPEC may be included at the conclusion of the cytoreductive surgery for the treatment of pseudomyxoma peritonei and appendix cancer if substantial tumor debulking is accomplished through CRS. HIPEC may be administered when complete removal of visible tumor (or debulking) is achieved through cytoreductive surgery; it involves perfusion of the peritoneal cavity with chemotherapy heated to approximately 40 degrees Celsius.

                                                                                                                                                                  HIPEC is administered with the infusion of heated chemotherapy during the last 90 minutes of the CRS procedure. Through HIPEC the surgeon(s) intend to destroy any residual tumor cells that may not have been surgically removed during the actual CRS surgery process.

                                                                                                                                                                  Although this procedure may initially sound drastic to the newly diagnosed patient, rarely is resection and/or removal of all of these organs is required. Each patient's case is unique and most patients live productive and healthy lives following surgery!


                                                                                                                                                                  Refer to our surgeons and specialists
                                                                                                                                                                  page for an international listing of HIPEC treatment providers.

                                                                                                                                                                  Where can I talk with other HIPEC patients?

                                                                                                                                                                  Want to learn more about preparing for and recuperating from HIPEC?

                                                                                                                                                                  Join the PMP Pals' Network HIPEC Pals' Resource Group today
                                                                                                                                                                  !


                                                                                                                                                                  Free help for HIPEC insurance "issues!"

                                                                                                                                                                  Who are the appendix cancer HIPEC treatment specialists?

                                                                                                                                                                  Click on any of the following website links to read more about HIPEC treatment
                                                                                                                                                                  :

                                                                                                                                                                  Pros and Cons of HIPEC: Need for Phase III Trials
                                                                                                                                                                  Source: Oncology Times, January 2007


                                                                                                                                                                  International Consensus of PSMG for CRS and HIPEC
                                                                                                                                                                  Source: Springerlink, Oct 2006


                                                                                                                                                                  AUSTRALIA
                                                                                                                                                                  St George's Hospital, Sydney

                                                                                                                                                                  Morbidity and Mortality: Study of HIPEC and CRS for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgery, Feb 2009, Dr David Morris, Dr Tristan Yan

                                                                                                                                                                  BELGIUM

                                                                                                                                                                  Dr Stefaan Mulier provides HIPEC treatment for Pseudomyxoma Peritonei and Peritoneal Carcinomatosis 
                                                                                                                                                                  Source: Leopold Park Clinic in Brussels


                                                                                                                                                                  Dr Wim P Ceelen, MD, PhD, FACS treats Pseudomyxoma Peritonei with HIPEC www.surgery.ugent.be

                                                                                                                                                                  CANADA

                                                                                                                                                                  Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Universite de Montreal, Canada, 2009

                                                                                                                                                                  FRANCE

                                                                                                                                                                  Treatment for Pseudomyxoma Peritonei
                                                                                                                                                                  Source: Institut Gustave Roussy, Cedex 2008

                                                                                                                                                                  GERMANY

                                                                                                                                                                  HIPEC treatment related articles...

                                                                                                                                                                  Safety of Gastric Resection During Cytoreductive Surgery Source: Annals of Surgical Oncology, 2009, Prof P Piso

                                                                                                                                                                  Quality of life following surgery for Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Dr Pompiliu Piso, 2009

                                                                                                                                                                  CRS and HIPEC for the Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Prof Pompiliu Piso, 3rd Annual Symposium, 2008

                                                                                                                                                                  CRS for Senior Patients
                                                                                                                                                                  Source: Dr Herwart Mueller, Germany
                                                                                                                                                                  Peritoneal Carcinomatosis
                                                                                                                                                                  Source: University of Erlangen Nuremberg 2006

                                                                                                                                                                  Improved Prognosis for Pseudomyxoma Peritonei and Appendix Cancer
                                                                                                                                                                  Source: German Medical Science, 2006

                                                                                                                                                                  Study with laboratory rats
                                                                                                                                                                  Source: Deutscher Krebskongress, 2004

                                                                                                                                                                  PHASE II STUDY FOR PERITONEAL CARCINOMATOSIS


                                                                                                                                                                  Professor P Piso, in Regensburg, Germany provides a prospective, multicenter Phase II study evaluating multimodality treatment with pre- and postoperative systemic chemotherapy with FOLFOX/Cetuximab or FOLFIRI/ Cetuximab, complete cytoreductive surgery (CRS), and HIPEC in patients with diagnosed with Peritoneal Carcinomatosis.

                                                                                                                                                                  For more information and to contribute to Prof Piso's research, contact him via:

                                                                                                                                                                  Leitender Oberarzt 
                                                                                                                                                                  Klinik und Poliklinik für Chirurgie
                                                                                                                                                                  der Universität Regensburg
                                                                                                                                                                  Franz Josef Strauß Allee 11
                                                                                                                                                                  D-93053 Regensburg

                                                                                                                                                                  Tel.:0941-944-6809
                                                                                                                                                                  Fax:0941-944-6860

                                                                                                                                                                  Source: Dr Piso provided this information to the PMP Pals' Network.

                                                                                                                                                                  GREECE

                                                                                                                                                                  Antonios-Apostolos K Tentes, M.D. Director of the Surgical Department at the Didimotichon General Hospital in Didmotichon Greece is conducting several clinical trials including one focused on colorectal cancer and one focused on gastric cancer.


                                                                                                                                                                  Colorectal Cancer: This study focuses on patients with colorectal cancer who have T3 and T4 tumors. The patients are randomly selected to undergo either surgery alone, or surgery combined with HIPEC, provided that R0 resection has been performed. The final goal of the study is compare the survival rates between these two groups of patients.

                                                                                                                                                                  Gastric Cancer: This study includes patients with T3 and T4 tumors. The patients undergo D2 gastrectomies and receive HIPEC.

                                                                                                                                                                  No further treatment is required. The goal of this study is to identify the survival and recurrence rates.


                                                                                                                                                                  For more information, contact:
                                                                                                                                                                  Dr Atonios-Apostolos K Tentes 
                                                                                                                                                                  Didimotichon General Hospital 
                                                                                                                                                                  Didimotichon, 68300, Greece

                                                                                                                                                                  ITALY
                                                                                                                                                                  Twelve year study of Pseudomyxoma Peritonei Treatment with CRS and HIPEC
                                                                                                                                                                  Source: San Giuseppe Hospital, June 2009

                                                                                                                                                                  Prognosis for Pseudomyxoma Peritonei following surgery
                                                                                                                                                                  Source: NCI, Milan, Italy 2009

                                                                                                                                                                  Prognosis for Pseudomyxoma Peritonei
                                                                                                                                                                  evaluating tumor markers following surgery
                                                                                                                                                                  HIPEC Treatment
                                                                                                                                                                  : Dott. Marcello Deraco: Pseudomyxoma Peritonei and
                                                                                                                                                                  Appendix Cancer
                                                                                                                                                                  Source: Dott. Marcello Deraco

                                                                                                                                                                  JAPAN

                                                                                                                                                                  Treatment of Appendix Cancer and Pseudomyxoma Peritonei
                                                                                                                                                                  Source: Pub Med 2009

                                                                                                                                                                  NEDERLAND/HOLLAND

                                                                                                                                                                  Peritoneal Carcinomatosis, Peritoneal Carcinomatosis and Appendix Cancer in Holland

                                                                                                                                                                  Cytoreduction and HIPEC Treatment for Appendix Cancer and Pseudomyxoma Peritonei (pdf)
                                                                                                                                                                  Source: Netherlands Cancer Institute, Prof VJ Verwaal, 2006

                                                                                                                                                                  USA

                                                                                                                                                                  HIPEC: UPMC Koch Cancer Treatment Center Pgh PA
                                                                                                                                                                  Source: UPMC Koch Cancer Treatment Center


                                                                                                                                                                  HIPEC: The Complexity of Clinical Trials
                                                                                                                                                                  Source: Dr David L Bartlett, UPMC, Society of Surgical Oncology 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Colorectal Carcinomatosis
                                                                                                                                                                  Source: Annals of Surgial Oncology, Nov 2008

                                                                                                                                                                  CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                  Source: Annuals of Surgical Oncology, 2008

                                                                                                                                                                  Treatment and Definition for the Treatment of Pseudomyxoma Peritonei and Appendix Cancer
                                                                                                                                                                  Source: University of Maryland

                                                                                                                                                                  Dr Martin Goodman provides HIPEC
                                                                                                                                                                  Source: Tufts, Boston

                                                                                                                                                                  Dr Perry Shen: Pseudomyxoma Peritonei and Appendix Cancer Treatment
                                                                                                                                                                  Source: Dr Perry Shen, WFU

                                                                                                                                                                  DPAM and and HIPEC Treatment
                                                                                                                                                                  Source: Wake Forest University


                                                                                                                                                                  Dr David L Bartlett; HIPEC Complexity
                                                                                                                                                                  Source: Society of Surgical Oncology

                                                                                                                                                                  Koch Cancer Center (Drs David L Bartlett, James Pingpank, Matthew Holtzman, S. Ahrendt)
                                                                                                                                                                  Source: UPMC Koch Cancer Center

                                                                                                                                                                  Dr Martin Goodman:Pseudomyxoma Peritonei and Appendix Cancer Treatment
                                                                                                                                                                  Source: Tufts 2009

                                                                                                                                                                  Dr Andrew Lowy: Pseudomyxoma Peritonei andAppendix  Cancer 
                                                                                                                                                                  http://health.ucsd.edu/cancer/patcare/gastro/appendiceal/

                                                                                                                                                                  Dr Jesus Esquivel: HIPEC Treatment

                                                                                                                                                                  HIPEC Treatment with Graph Description
                                                                                                                                                                  Source:Dr Jesus Esquivel HIPEC.org

                                                                                                                                                                  Dr Jesus Esquivel:
                                                                                                                                                                  Pseudomyxoma Peritonei and Appendix Cancer Treatment
                                                                                                                                                                  Source: Dr Jesus Esquivel, St Agnes

                                                                                                                                                                  Pros and Cons of HIPEC: Dr Jesus Esquivel
                                                                                                                                                                  Source: Oncology Times, Jan 2007

                                                                                                                                                                  Dr Armando Sardi:CRS and HIPEC offer longterm survival for Peritoneal Carcinomatosis of disseminated Appendiceal tumor origin
                                                                                                                                                                  Source: Dr Armando Sardi, Mercy Med Center, Journal of American College of Surgeons, Sept 2009

                                                                                                                                                                  Dr Paul Sugarbaker evaluates perioperative chemotherapy agents for treatment of Pseudomyxoma Peritonei
                                                                                                                                                                  Source: The Oncolgist, Feb 2005

                                                                                                                                                                  ASCO Summaries for post op prognosis of Pseudomyxoma Peritonei
                                                                                                                                                                  Source: ASCO
                                                                                                                                                                  Phase I Study for Appendix Cancer
                                                                                                                                                                  Source: NIC and WFU, 2009

                                                                                                                                                                  HIPEC for Pseudomyxoma Peritonei and Peritoneal Carcinomatosis Treatment


                                                                                                                                                                  Surgery with HIPEC (pdf)

                                                                                                                                                                  HIPEC for OB/GYN

                                                                                                                                                                  HIPEC: Intraoperative HIPEC Treatment w/Cisplatin for Peritoneal Carcinomatosis of Ovarian Origin

                                                                                                                                                                  Health Insurance Coverage for HIPEC
                                                                                                                                                                  Insurance and Appeals assistance for HIPEC coverage of payment
                                                                                                                                                                  Source: ThermaSolutions, Inc.

                                                                                                                                                                  See Health Insurance

                                                                                                                                                                  Medicare "code" for HIPEC treatment: 96445     

                                                                                                                                                                  Appeals for Insurance Denials

                                                                                                                                                                  How to Appeal a Denial from your Health Insurance Provider (including denials for HIPEC treatment)

                                                                                                                                                                  HIPEC Video

                                                                                                                                                                  HIPEC Video: Intraperitoneal Hyperthermic Perfusion
                                                                                                                                                                  This video includes graphic scenes of surgery being peformed.
                                                                                                                                                                  Source:You Tube: Perfusion Network, National Cancer Institute of Milan, Italy


                                                                                                                                                                  International consensus statement regarding HIPEC

                                                                                                                                                                  HIPEC Consensus Statement 2006
                                                                                                                                                                  Source: Springerlink 2006


                                                                                                                                                                  Legal and Safety Considerations for HIPEC Administration

                                                                                                                                                                  Legal and Safety Considerations of Administering HIPEC, Risk/Benefit Analysis for HIPEC, Morbidity-Mortality, Protection of Medical Personell During Administration of HIPEC, Biohazard Management of HIPEC, OSHA, NOSH, Certification
                                                                                                                                                                  Source: Centre Hospitalier Lyon Sud, Pierre Benite, France, 2008



                                                                                                                                                                  HIPEC, General Interest for Appendix Cancer, Peritoneal Carcinomatosis and Pseudomyxoma Peritonei Patients

                                                                                                                                                                  Terumo Medical Corporation
                                                                                                                                                                  Manufacturerer of HIPEC perfusion equipment


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