CURRICULUM
VITAE
PRESENT POSITONS: Vice
Chairman, Program Director and
Director of Surgical Oncology
Department of Surgery
University of North Dakota
School of Medicine and Health Sciences 501 North Columbia Road
Telephone (701) 777- 3067
Fax (701) 777-2609
Email – rsticca@medicine.nodak.edu
Surveyor, American College of Surgeons,
Commission on Cancer
American College of Surgeons
633 North Saint Clair Street
Chicago, Illinois 60611-3211
Telephone (312) 202-5085
Fax (312) 202-5009
EDUCATION: A.A. (Liberal Arts, Magna Cum Laude) 1973-1976
Springfield Technical Community College
Springfield, Massachusetts
B.A. (Microbiology, Magna Cum Laude) 1977-1979
University of New Hampshire
Durham, New Hampshire
M.D. 1980-1984
University of Connecticut School of Medicine
Farmington, Connecticut
POST GRADUATE
TRAINING: Internship:
General Surgery 1984-1985
Boston University Surgical Training Program
Boston, Massachusetts
Residency:
General Surgery 1985-1988
Boston University Surgical Training Program
Boston, Massachusetts
Chief Resident
General Surgery 1988-1989
Boston University Surgical Training Program
Boston, Massachusetts
Fellowship:
Surgical Oncology 1992-1993
Roswell Park Cancer Institute
Buffalo, New York
BOARD CERTIFICATION: American Board of Surgery 1990
Certificate No. - 35434
Recertification 1997
MILITARY: Major 1987-1991
United States Air Force Medical Corps
Captain 1982-1987
United States Army Reserve Medical Corps
ACADEMIC APPOINTMENTS: Vice Chairman and Program
Director 2003-Present
University of North Dakota
School of Medicine and Health Sciences
Grand Forks, North Dakota
Associate Professor of Surgery 2003-Present
University of North Dakota
School of Medicine and Health Sciences
Grand Forks, North Dakota
Associate Director, Department of Surgical
Education 1993-2003
Greenville Hospital System Division for
Academic Services
Greenville, South Carolina
Program Director (Interim), Department of
Surgical Education 2002-2003
Greenville Hospital System Division for
Academic Services
Greenville,
South Carolina
Associate Professor of Surgery 1998-2003
University of South Carolina School of Medicine
Columbia, South Carolina
Assistant Professor of Surgery 1993-1998
University of South Carolina School of Medicine
Columbia, South Carolina
Associate Professor of Surgery 1998-2003
Medical University of South Carolina
Charleston, South Carolina
Assistant Professor of Surgery 1993-1998
Medical University of South Carolina
Charleston, South Carolina
Biomedical Professor 1995-2003
GHS/Clemson University Biomedical Cooperative
Clemson, South Carolina
Clinical Assistant Instructor 1992-1993
Department of Surgery
State University of New York Buffalo
School of Medicine and Biomedical Sciences
Roswell Park Cancer Institute
Clinical Assistant Instructor 1992-1993
Department of Emergency Medicine
State University of New York at Buffalo
School of Medicine and Biomedical Sciences
HONORS AND SCHOLARSHIPS: Phi Beta
Kappa, University of New
Hampshire 1979
Alpha
Epsilon Delta, University of
New
Hampshire 1979
Connecticut
Graduate Student
Scholarship 1980
University
of Connecticut Health
Center
Association Scholarship 1980,
1983
Hartford
County Medical Association
Scholarship 1982,
1983
Scholar
in Medicine, University of
Connecticut
School of Medicine 1984
Mosby
Scholarship, Book Award for Clinical
Excellence 1984
MILITARY HONORS: Meritorious
Service Medal
Air
Force Achievement Medal
Outstanding
Company Grade Officer of the Quarter
National
Defense Service Medal
Air
Force Outstanding Unit Award
Army
Reserve Components Achievement Medal
PROFESSIONAL SOCIETIES: Current:
American Association for Cancer Research
American
College of Surgeons – Fellow
American
Medical Association
American
Society of Clinical Oncology
Association
of Program Directors in Surgery
Association
for Surgical Education
Massachusetts
Medical Society
Roswell
Park Surgical Society
Society
of Gastrointestinal Endoscopic Surgeons
Society
of Surgical Oncology
Southeastern Surgical Congress
Prior:
American College of Physician Executives
Greenville
County Medical Society
South
Carolina Medical Society
South
Carolina Surgical Society
Vice
President, Program Director 1998-1999
COMMUNITY ACTIVITIES: Hospice Professional Advisory Committee,
Greenville
Hospital System 1996 - 1999
Susan B. Komen Foundation, Upstate South Carolina Race for The Cure
Race Director 1995
Board of Directors 1995-2003
Chairman, Board of Directors 1998-2000
Greenville
Free Medical Clinic
Volunteer
Physician 1994-2003
HOSPITAL/UNIVERSITY
COMMITTEES & RESPONSIBILITIES:
Current: University of North Dakota School
of Medicine Graduate
Medical Education Committee
Director of Surgical Oncology
Altru Health System
Cancer
Liason Physician, American College of
Surgeons Commission on Cancer
Cancer Committee
Prior: Greenville Hospital System:
Administrator, Oncology Service Unit
Cancer
Care Committee
Cancer Liaison Physician, American College of
Surgeons Commission on Cancer
Chairman, Cancer Care Committee
Chairman,
Cancer Conference
Chairman, Oncology Section, Medical Staff
Chief, Surgical Oncology
Infection Control Committee
Medical Care Committee
Medical Director, Breast Health Center
Medical Director, Cancer Center Medical
Director, Cancer Registry
Point of Care Committee
Utilization Review Committee
Patrick Air Force Base Hospital:
Infection Control Committee
Tumor Board
CLINICAL RESEARCH: Principal
Investigator, Greenville Hospital System
Cancer Center/Oncology Research
Institute
Protocol CC/ORI 02-01. Phase II Trial of
Dendritic Cell Vaccines for Patients with
Advanced Melanoma.
2002-Present
Principal Investigator,
Greenville Hospital System
Cancer Center/Oncology Research Institute
Protocol CC/ORI 00-01. Treatment of
Patients with Disseminated Melanoma using Dendritic Cells Fused with Irradiated
Tumor Cells as a Cancer Vaccine in Conjunction with IL-2.
1999-Present
Principal Investigator,
Greenville Hospital System
Cancer Center/Oncology Research Institute
Protocol CC/ORI 00-03. Treatment of Patients
with Metastatic Renal Cell Carcinoma using
Dendritic Cells Fused with Irradiated Tumor
Cells as a Cancer Vaccine in Conjunction with
IL-2. 2001-Present
Principal Investigator, Greenville Hospital System
Component, Greenville CCOP 2000-2003
Principal Investigator, Greenville Hospital System
Component, Upstate Carolina CCOP 1996-2000 Principal Investigator, NSABP
Breast Cancer Prevention Trial 1993-2003
Principal
Investigator, NSABP
STAR Trial 1999-2003
Principal
Investigator, NSABP
Upstate Carolina CCOP 1996-2000
Medical
Director, Oncology Clinical Research
Office, Greenville Hospital System 1995-2003
Director,
Greenville Hospital System
Tissue
Bank 1995-2000
BASIC SCIENCE RESEARCH
INTERESTS: Dendritic cell vaccines for solid tumors.
Thymidylate synthase variation in human
colorectal
tumors.
PUBLICATIONS:
1.
Sticca RP, Palmer ML. Polyp of the Appendix. New England Journal of Medicine. 329(23),
1709, 1993.
2.
McAlhany JC, Taylor
SM, Sticca RP, Ashmore JD, Hanover
TM. Long
Term Follow-up with Roux-en-Y Gastrojejunostomy for the Treatment of Gastric
Disease. Annals of Surgery. 219(5),
451-457, 1994.
3.
Sticca RP, Spellman J,
Perez-Mesa C, Karakousis CP. Advanced neurofibromatosis of the lower
extremity requiring hemipelvectomy. Surgical Rounds. 18(9), 367-372, 1995.
4.
Sticca RP,
Rodriguez-Bigas M, Penetrante RB, Petrelli NJ.
Curative Resection for Stage I
Rectal Cancer: Natural History,
Prognostic Factors and Recurrence Patterns. Cancer Investigation. 14 (5), 491-497, 1996.
5.
Sticca, RP,
Weatherford DA, McAlhany JC. Carcinoma of the Ampulla of Vater: A Community Hospital Experience. The American Surgeon. 62(3), 197-202, 1996.
6.
Taylor SM, Weatherford
DA, Carsten CG, Sticca RP, Langan
EM. The
Routine Use of Implantable Subcutaneous Infusion Ports: An Outcome Analysis in an Oncology
Population. American College of
Surgeons Surgical Forum. 47, 657-659, 1996.
7.
Jones GB, Kilgore MW,
Pollenz RS, Li A, Mathews JE, Wright JM, Huber RS, Tate PL, Price TL, Sticca
RP. Target directed enediyne prodrugs: hER and
AhR degradation by a synthetic oxo-enediyne. Bio-organic & Medicinal Chemistry Letters. 6 (16), 1971-76,
1996.
8.
Gouldman JW, Sticca
RP, Rippon MD, McAlhany JC. Laparoscopic Cholecystectomy
in Pregnancy. The American Surgeon. 64(1), 93-98, 1998.
9.
Chen WY, Ramamoorthy
P, Chen NY, Sticca RP, Wagner TE, A Human Prolactin Antagonist, hPRL-G129, Inhibits
Breast Cancer Cell Proliferation through Induction of Apoptosis. Clinical Cancer Research. 5(11), 3583-3593, 1999.
10.
Wei Y, Li J, Chen WY,
YuX, Sticca RP, Wagner TE. Enhanced Transgene Expression and
Effective in Vivo Anti-Tumor Immune Responses Initiated by Dendritic
Progenitors Transfected with a Non-Viral T7 Vector Expressing A Model Tumor
Antigen. Journal of Immunotherapy. 23(1), 75-82, 2000.
11.
Cataldo L, Chen NY,
Yuan Q, Li W, Ramamoorthy P, Wagner TE, Sticca RP, Chen WY. Inhibition of Oncogene STAT3 Phosphorylation by a Prolactin Antagonist,
hPRL-G129R, in T-47D Human Breast Cancer Cells. International Journal of Oncology. 17, 1179-1185, 2000.
12.
Ramamoorthy P, Sticca
R, Wagner TE, Chen WY. In
Vitro Studies of a Prolactin Antagonist, hPRL-G129R in Human Breast Cancer
Cells. International Journal of
Oncology. 18, 25-32, 2001.
13.
Holmes LM, Li J, Sticca
RP, Wagner TE, Wei Y. A
Rapid, Novel Strategy to Induce Tumor Cell Specific Cytotoxic T Lymphocyte
Responses Using Instant Dendritomas. Journal
of Immunotherapy. 24(2), 122-129, 2001.
14.
Schwab DP, Blackhurst
DW, Sticca RP. Operative
Acute Small Bowel Obstruction – Admitting Service Impacts Outcome. The American Surgeon. 67, 1034-1040, 2001.
15.
Yousef AM, Davis RA, Sticca
RP, Berger SH. Structural Analysis of cDNA
Encoding Thymidylate Synthase in Hepatic Metastases of Human Colorectal
Tumors. International Journal of
Colorectal Disease. 16, 318-325, 2001.
16.
Jones GB, Wright JM,
Hynd G, Wyatt JK, Warner PM, Huber RS, Li A, Kilgore MW, Sticca RP, Pollenz RS.
Oxa-enediynes: probing the electronic
and stereoelectronic contributions to the Bergman cycloaromatization. Journal of Organic Chemistry.
67(16), 5727-32, 2002.
17.
Sticca RP, Dach
BW. Rationale
for Hyperthermia with Intraoperative Intraperitoneal Chemotherapy Agents.
Surgical Oncology Clinics of North America. 12(3), 689-701, 2003.
18.
Patel AP, Harris JB,
Lokey JS, Sticca RP, McGill ES,
Arrillaga A, Miller RS, Kopelman TR. Current Management of Common Bile Duct
Stones in a Teaching Community Hospital. American Surgeon. 69(7), 555-61, 2003.
19.
Wei Y, Li J, Sticca
R, Holmes L, Burgin K, Smith S, Williamson J,
Wagner T. Phase I Trial of Autologous Dendritic Cell Vaccine for Stage IV
Malignant Melanoma. Manuscript in
preparation.
20.
Sticca RP, Syribeys
PJ, West L. Liposarcoma of the Spermatic Cord: Implications for the General
Surgeon. Manuscript in Preparation.
21.
Sticca RP, Dameron
J. Transthoracic
versus Transhiatal Esophagectomy for the Management of Esophageal
Carcinoma. Manuscipt in
Preparation.
EDITORIALS, COMMENTARIES,
LETTERS:
1. Sticca, RP. Letter to the Editor Response
to Polyp of the Appendix. New
England Journal of Medicine. 330(16), 1159, 1992.
2. Coker AL,
Crane MM, Sticca RP, Bradlow HL. Re:
Ethnic Differences in Estrogen
Metabolism in Healty Women. Journal of the National Cancer
Institute. 89(1), 89-90, 1997.
3. Sticca
RP. Divided Gastric Bypass (Discussion). The American Surgeon. 64(1), 65-66, 1998.
4. Sticca RP. Peritoneal Carcinomatosis, The Last Frontier. Annals of Surgical Oncology. 10(5), 484-5, 2003.
PUBLISHED ABSTRACTS:
1.
Pietrafitta JJ, Sticca
RP. Malignant
Esophageal Obstruction, 50 Patients Treated with the ND: Yag Laser
Using the Retrograde Technique.
Gastrointestinal Endoscopy.
3(152), 1987.
2.
Sticca RP,
Rodriguez-Bigas MA, Petrelli NJ. Recurrence Patterns in Stage I
Adenocarcinoma of the Rectum.
Proceedings American Society of Clinical Oncology. 12(224), 1993.
3.
Davis R.A., Sticca
RP, Dunlap RM, Berger FG, Berger SH, Thymidylate Synthase Variation in Human
Colonic Tissues. Proceedings
American Association for Cancer Research, 37, 1996.
4.
Ramamoorthy P, Sticca
RP, Wagner TE, Chen WY. A
Human Prolactin Receptor Antagonist, hPRL – G129R, Induces Apoptosis in Breast
Cancer Cells. Proceedings American
Association for Cancer Research, 40 (1108), 1999
5.
Chen WY, Long Y,
Ramamoorthy P, Wei Y, Sticca RP, Wagner
TE. Inhibitory
Effects of a Prolactin Antagonist in Human Breast Cancer Cell Proliferation and
Its Synergistic Action in Conjunction with Tamoxifen. Proceedings American Association for Cancer
Research. 40 (4840), 1999.
6.
Sticca RP, Li J, Chen
W, Yu X, Wagner TE, Wei Y. Effective In Vivo Anti-Tumor Immune
Responses With T7 Vector Transfected Dendritic Progenitor Cells. Proceedings American Society of Clinical
Oncology, 18 (2398), 1999.
7.
Wei Y, Li J, Chen WY,
Yu X, Sticca RP, Wagner TE. Enhanced
Transgene Expression by Bone Marrow Derived Dendritic Progenitor Cells
Transfected with a Non-Viral T7 Vector. Proceedings American Association
for Cancer Research, 40 (4334), 1999.
8.
Yousef AF, Davis RA, Sticca
RP, and Berger SH. Determination of
Thymidylate Synthase Levels in Human Colonic Metastases. Proceedings American Association for Cancer
Research, 40 (2248), 1999.
9.
Yousef AM, Sticca
RP, and Berger SH. TS Gene Structure and TS
Expression. Proceedings of the
American Association of Cancer Research, 41 (1114), 2000.
10.
Chen NY, Li W, Cataldo
L, Sticca RP, Wagner TE, and Chen
WY. In
Vivo Studies of the Anti-Tumor Effects of a Human Prolactin Antagonist,
hPRL-G129R, in Nude Mice. Proceedings
of the American Association of Cancer Research, 42 (2006), 2001.
11.
Holmes LM, Li J, Sticca
RP, Wagner TE, and Wei Y. A
Rapid, Novel Strategy to Induce Tumor Cell Specific Cytotoxic T Lymphocyte
(CTL) Responses Using Instant Dendritomas Proceedings American Association
for Cancer Research, 42 (1485), 2001.
12.
Sticca R, Smith S, Holmes L, Li J, Burgin K,
Williamson J, Wagner T, Wei Y. Phase I Trial of Autologous Dendritic Cell
Vaccine for Stage IV Malignant Melanoma.
Proceedings American Society of Clinical Oncology, 22 (712), 2003.
PRESENTATIONS (National and Regional Meetings):
1.
“Hormone Dependent Carcinomas, Indications for
Hormone Treatment or Blockade”. Cancer Symposium – Panel Discussion
– Case Presentations. Greenville, South
Carolina. April 29, 1994.
2.
“Colorectal Cancer and Lymphoma: Association or Coincidence”. J.D.
Ashmore Lectureship. Greenville, South Carolina. June 18, 1994.
3.
“Management of Ampullary Carcinoma: Current Status and Institutional Review”, South Carolina Surgical Society. Asheville, North Carolina. June 25, 1994.
4.
“Carcinoma of the Ampulla of Vater: A Community Hospital Experience”. Southeastern Surgical Congress. New Orleans, LA. February 8, 1995.
5.
“Theories of Tumor Dissemination: Halstead to Fisher”. South
Carolina Chapter, American College of Surgeons. Charleston, South
Carolina. February 10, 1995
6.
Current Controversies in Cancer Surgery, Moderator. South Carolina Chapter, American
College of Surgeons. Charleston, South
Carolina. February 10, 1995.
7.
“Thymidylate Synthase Variation in Human Colorectal
Tumors”. J.D. Ashmore
Lectureship. Greenville, South
Carolina. June 17, 1995.
8.
“Endoscopic Sphincterotomy: Techniques for Cutting
the Difficult Papilla”. Discussant.
Southeastern Surgical Congress.
New Orleans, LA. February 5-8,
1995.
9.
“Thymidylate Synthase Levels in Colorectal Liver
Metastasis”. J.D. Ashmore
Lectureship. Greenville, South
Carolina. June 15, 1996
10.
“Divided Gastric Bypass, A 15 year Experience”.
Discussant. Southeastern Surgical Congress, Nashville, Tennessee. February 2-5, 1997.
11.
“Management of Splenic Cysts, Case Report and Review
of Literature.” South Carolina
Surgical Society. Sea Island, Georgia.
June 6, 1997
12.
“Accessory Spleen After Laparoscopic Splenectomy.” J.D. Ashmore Lectureship. Greenville, South Carolina.
June 20, 1997
13.
“Recent Advances in Genetic Oncology Research.” South Carolina Cancer Registrars Association Annual
Meeting. Greenville, South
Carolina. November 6-7, 1997.
14.
“Effective In-Vivo Anti-tumor Immune Responses with
T7 Vector Transfected Dendritic Progenitor Cells.” American Society of Clinical Oncology. Atlanta, Georgia May 15-19, 1999
15.
“Radioguided Surgery and Radioguided Sentinel
Lymph Node Biopsy in Malignant Melanoma.”
South Carolina Surgical Society, Asheville, North Carolina, June 11-12,1999.
16.
“Laparoscopic Surgery in Pregnancy.” J.D. Ashmore Lectureship, Greenville, South
Carolina. June 18, 1999
17.
“Dendritic Cell Vaccines for Malignant
Melanoma.” J.D. Ashmore Lectureship, Greenville, South
Carolina. June 23, 2000
18.
“Biologic Therapy for Cancer.” South
Carolina Cancer Registrars Annual Meeting.
Spartanburg, South Carolina.
March 15, 2001
19.
“Pseudomyxoma Peritonei, Surgical Debulking and
Heated Intraoperative Intraperitoneal Chemotherapy.” J.D. Ashmore
Lecturship, Greenville, South Carolina.
June 15, 2001
POSTER PRESENTATIONS:
1.
Davis RA, Berger SH,
Dunlap RB, Berger FG, Sticca RP, Burns
R, McFarland J, Greene F: Thymidylate
Synthase Variation in Human Colorectal Tumors, 4th South
Carolina Statewide Research Conference, Isle of Palms, South Carolina, January
2- 4, 1995.
2.
Davis RA, Sticca
RP, Dunlap RM, Berger FG, Berger SH. Thymidylate
Synthase Variation in Human Colonic
Tissues. 5th South Carolina Statewide Research Conference. Isle
of Palms, South Carolina, January 4-6,
1996.
3. Sticca RP, D’Emilia JC: Laparoscopic Staging Procedure for Hodgkin’s Disease. Southeastern Surgical Congress, 64th Annual Meeting, Tampa, Florida, February 4-7,1996.
4.
Davis RA, Sticca
RP, Dunlap RM, Berger FG, Berger SH: Thymidylate
Synthase Variation in Human Colonic
Tissues. American Association for
Cancer Research, 87th Annual Meeting, Washington, DC, April 20-24,
1996.
5.
Al-Motassem RY, Hall
JK, Davis RA, Sticca RP, Berger
SH. Liver
Metastasis from Patients Previously Treated with 5-Flourouracil Regimens
Exhibit Low Fdump Binding. 7th South Carolina Statewide Research
Conference, Isle of Palms, South Carolina, January 4-6, 1998.
6.
Crane MM, Sepkovic D,
Robertson NR, Sticca RP, Bradlow HL.
Selected Urinary Estrogen
Metabolites and Risk of Breast Cancer.
American Society of Preventive Oncology. Bethesda, Maryland. March
4-6, 1998.
7.
Ramamoorthy P, Sticca
RP, Wagner TE, Chen WY. A
Human Prolactin Receptor Antagonist,
hPRL – G129R, Induces Apoptosis in Breast Cancer Cells. American Association for Cancer Research, 90th
Annual Meeting, Philadelphia, Pennsylvania. April 10-14, 1999.
8.
Chen WY, Long Y,
Ramamoorthy P, Wei, Sticca RP, Wagner
TE. Inhibitory Effects of a Prolactin
Antagonist in Human Breast Cancer Cell Proliferation and its Synergistic Action
in Conjunction with Tamoxifen. American Association for Cancer Research. 90th
Annual Meeting. Philadelphia,
Pennsylvania. April 10-14, 1999.
9.
Wei Y, Li J, Chen WY,
Yu X, Sticca RP, Wagner TE. Enhanced Transgene Expression by Bone Marrow Derived Dendritic Progenitor
Cells Transfected with a Non-Viral T7 Vector. American Association for Cancer Research. 90th Annual
Meeting. Philadelphia, Pennsylvania.
April 10-14, 1999.
10.
Yousef AF, Davis RA, Sticca
RP, Berger SH. Determination of
Thymidylate Synthase Levels in Human
Colonic Metastasis. American
Association of Cancer Research. 90th Annual Meeting. Philadelphia, Pennsylvania. April 10-14, 1999.
11. Cordray TL, Abrams RS, <